Postgraduate Program in Dentistry, Universidade Federal Do Paraná, Curitiba, Paraná, Brazil.
Department of Oral and Maxillofacial Surgery, Erasto Gaertner Cancer Center, Curitiba, Paraná, Brazil.
Support Care Cancer. 2021 Nov;29(11):6713-6719. doi: 10.1007/s00520-021-06275-w. Epub 2021 May 10.
Cancer and its therapies can have a significant impact on general and oral health and, therefore, cause a reduction in patients' quality of life (QoL). The study aimed to evaluate the QoL of cancer patients who use antiresorptive and anti-angiogenic medications with or without the development of medication-related osteonecrosis of the jaws (MRONJ).
Sixty-two patients diagnosed with cancer under antiresorptive therapy answered three instruments from the European Organization for Cancer Research and Treatment (EORTC). The first questionnaire (QLQ-C30) aimed to measure the overall QoL, the second (QLQ-ELD14) is a complementary module for elderly patients, and the third (QLQ-OH15) aimed to assess oral health related to QoL.
The mean age of the patients was 62.19 years, and 12.9% developed MRONJ. There was no significant difference between sex and MRONJ. Among the QLQ-C30 scales, the item "role functioning (RF2)" presented a significant result (p = 0.019). Those patients without MRONJ had a better function performance both in their daily chores and in their free time. Age was not associated to MRONJ, although some concerns are common to the elderly and cancer patients. QoL related to oral health presented a significant result (p = 0.048) showing that MRONJ has a negative impact on patients' QoL.
Our results showed that MRONJ has a significant impact on the general and oral QoL of cancer patients, and therefore prevention and awareness must be a priority.
癌症及其治疗方法会对整体健康和口腔健康产生重大影响，从而降低患者的生活质量（QoL）。本研究旨在评估使用抗吸收和抗血管生成药物的癌症患者的 QoL，无论是否发生药物相关性颌骨坏死（MRONJ）。
62 名接受抗吸收治疗的癌症患者回答了欧洲癌症研究与治疗组织（EORTC）的三个问卷。第一个问卷（QLQ-C30）旨在测量整体 QoL，第二个（QLQ-ELD14）是专为老年患者设计的补充模块，第三个（QLQ-OH15）旨在评估与 QoL 相关的口腔健康。
患者的平均年龄为 62.19 岁，12.9%发生了 MRONJ。性别与 MRONJ 之间无显著差异。在 QLQ-C30 量表中，“角色功能（RF2）”项目呈现显著结果（p=0.019）。无 MRONJ 的患者在日常家务和休闲时间的功能表现更好。年龄与 MRONJ 无关，但一些老年人和癌症患者共有的问题需要关注。与口腔健康相关的 QoL 呈现显著结果（p=0.048），表明 MRONJ 对患者的 QoL 有负面影响。
我们的结果表明，MRONJ 对癌症患者的整体和口腔 QoL 有重大影响，因此预防和意识必须是优先事项。
