化脓性瘢痕疙瘩：严重瘢痕疙瘩病的并发症。
Suppurative keloids: a complication of severe keloid disease.
机构信息
Dermatology Department, APHP, Saint Louis University Hospital, Paris, France.
University of Paris, Paris, France.
出版信息
Int J Dermatol. 2021 Nov;60(11):1392-1396. doi: 10.1111/ijd.15641. Epub 2021 May 11.
BACKGROUND
Some keloids show cystic cavities that give rise to acute inflammatory flares and oozing. These suppurative keloids (SK) have rarely been systematically studied. We conducted a retrospective cohort study to evaluate SK frequency and its risk factors. We also reviewed microbiological analyses as well as the histological features of removed SKs.
METHODS
Between July 1, 2015, and September 30, 2016, all adult patients attending a specialized keloid clinic were asked to participate. Clinical information and microbiological results were extracted from each patient's file. Histological features were observed and interpreted.
RESULTS
In this study, we observed an SK rate of 26% for a mean keloid history of 17.2 years. Male gender, African ancestry, and a family history of keloids were significantly associated with suppuration. Microbiological examination revealed commensal skin flora 7/9 (77.8%), Staphylococcus aureus 1/9 (11.1%), and Enterococcus faecalis 1/9 (11.1%).
CONCLUSION
Suppuration is a common complication of keloids occurring in patients with severe keloid disease and may arise from pilosebaceous occlusion and aseptic inflammation.
背景
有些瘢痕疙瘩会出现囊性腔隙，导致急性炎症发作和渗出。这些化脓性瘢痕疙瘩（SK）很少被系统研究。我们进行了一项回顾性队列研究，以评估 SK 的频率及其危险因素。我们还回顾了微生物分析以及切除的 SK 的组织学特征。
方法
在 2015 年 7 月 1 日至 2016 年 9 月 30 日期间，我们邀请所有到专门的瘢痕疙瘩诊所就诊的成年患者参与。从每位患者的档案中提取临床信息和微生物学结果。观察和解释组织学特征。
结果
在这项研究中，我们观察到化脓率为 26%，瘢痕疙瘩病史平均为 17.2 年。男性、非洲裔和瘢痕疙瘩家族史与化脓显著相关。微生物学检查显示 7/9（77.8%）为共生皮肤菌群，1/9（11.1%）为金黄色葡萄球菌，1/9（11.1%）为粪肠球菌。
结论
化脓是瘢痕疙瘩的常见并发症，发生在严重瘢痕疙瘩疾病的患者中，可能由毛囊皮脂腺阻塞和无菌性炎症引起。
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