Department of Plastic Surgery, Peking Union Medical College Hospital, Beijing, China.
Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Int Wound J. 2023 Aug;20(6):2215-2223. doi: 10.1111/iwj.14099. Epub 2023 Feb 6.
Keloid infections reduce patient-reported quality of life greatly. Characteristics and risk factors of keloid infections have not been thoroughly studied. So, a retrospective cohort study was conducted focusing on the potential risk factors, microbiologic cultures and histological findings. Keloid patients consulting for surgical interventions were included in this study. Data were collected from their electronic medical records. 564 patients were recruited with the keloid infection rate being 22.4%. For adult patients, age above 40 years (OR, 2.84; P = .000), disease duration of 12 years or more (OR, 3.03; P = .000), the number of keloids over 3 (OR, 1.59; P = .050) and the presence of family history (OR, 1.91; P = .027) were significantly associated with keloid infections. Suppurative keloids were located mostly in thorax (61.79%). For the under-age subgroup(n = 25), family history was frequently seen in patients with infections. Microbiologic cultures revealed a mixed spectrum of bacteria including Staphylococcus (25%), Actinomyces (30%) and Prevotella (10%). The rate of epidermoid cysts was 19.7% in histological examination. Age > 40 years, disease duration ≥12 years, the number of keloids >3 and the presence of family history are risk factors for keloid infections.
瘢痕疙瘩感染极大地降低了患者报告的生活质量。瘢痕疙瘩感染的特征和危险因素尚未得到彻底研究。因此，进行了一项回顾性队列研究，重点研究潜在的危险因素、微生物培养和组织学发现。本研究纳入了咨询手术干预的瘢痕疙瘩患者。从他们的电子病历中收集数据。共招募了 564 名患者，瘢痕疙瘩感染率为 22.4%。对于成年患者，年龄>40 岁（OR，2.84；P =.000）、疾病持续时间>12 年（OR，3.03；P =.000）、瘢痕疙瘩数量>3 个（OR，1.59；P =.050）和家族史（OR，1.91；P =.027）与瘢痕疙瘩感染显著相关。化脓性瘢痕疙瘩多位于胸部（61.79%）。在年龄较小的亚组（n=25）中，感染患者常伴有家族史。微生物培养显示出包括葡萄球菌（25%）、放线菌（30%）和普雷沃氏菌（10%）在内的混合细菌谱。组织学检查中表皮样囊肿的发生率为 19.7%。年龄>40 岁、疾病持续时间≥12 年、瘢痕疙瘩数量>3 个和家族史存在是瘢痕疙瘩感染的危险因素。
