Intraoperative Imaging Unit, Chair and Department of Neurosurgery and Neurotraumatology, Karol Marcinkowski University of Medical Sciences, Przybyszewskiego 49, 60-355, Poznan, Poland; Department of Neurosurgery and Neurotraumatology, Heliodor Swiecicki Clinical Hospital, Przybyszewskiego 49, 60-355, Poznan, Poland.
Chem Biol Interact. 2021 Aug 1;344:109501. doi: 10.1016/j.cbi.2021.109501. Epub 2021 May 8.
The pandemic of SARS-CoV-2 stimulates significant efforts and approaches to understand its global spread. Although the recent introduction of the vaccine is a crucial prophylactic step, the effective treatment for SARS-CoV-2 is still undiscovered. An in-depth analysis of symptoms and clinical parameters, as well as molecular changes, is necessary to comprehend COVID-19 and propose a remedy for affected people to fight that disease. The analysis of available clinical data and SARS-CoV-2 infection markers underlined the main pathogenic process in COVID-19 is cytokine storm and inflammation. That led us to suggest that the most important pathogenic feature of SARS-CoV-2 leading to COVID-19 is oxidative stress and cellular damage stimulated by iron, a source of Fenton reaction and its product hydroxyl radical (•OH), the most reactive ROS with t-10s. Therefore we suggest some scavenging agents are a reasonable choice for overcoming its toxic effect and can be regarded as a treatment for the disease on the molecular level.
SARS-CoV-2 大流行激发了人们极大的努力和方法来理解其在全球范围内的传播。尽管最近引入了疫苗是预防的重要步骤，但仍未发现针对 SARS-CoV-2 的有效治疗方法。深入分析症状和临床参数以及分子变化，对于理解 COVID-19 并为受影响的人们提出治疗该疾病的方法是必要的。对现有临床数据和 SARS-CoV-2 感染标志物的分析强调了 COVID-19 中的主要发病过程是细胞因子风暴和炎症。这使我们认为，导致 COVID-19 的 SARS-CoV-2 的最重要的发病特征是由铁引起的氧化应激和细胞损伤，铁是 Fenton 反应及其产物羟基自由基（•OH）的来源，•OH 是最具反应性的 ROS，t-10s。因此，我们建议一些清除剂是克服其毒性作用的合理选择，并且可以被视为在分子水平上治疗该疾病的方法。
