Ivimey-Cook Edward R, Sales Kris, Carlsson Hanne, Immler Simone, Chapman Tracey, Maklakov Alexei A
School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich NR4 7TU, UK.
Proc Biol Sci. 2021 May 12;288(1950):20210701. doi: 10.1098/rspb.2021.0701.
Dietary restriction (DR) increases lifespan in a broad variety of organisms and improves health in humans. However, long-term transgenerational consequences of dietary interventions are poorly understood. Here, we investigated the effect of DR by temporary fasting (TF) on mortality risk, age-specific reproduction and fitness across three generations of descendants in . We show that while TF robustly reduces mortality risk and improves late-life reproduction of the individuals subject to TF (P), it has a wide range of both positive and negative effects on their descendants (F-F). Remarkably, great-grandparental exposure to TF in early life reduces fitness and increases mortality risk of F descendants to such an extent that TF no longer promotes a lifespan extension. These findings reveal that transgenerational trade-offs accompany the instant benefits of DR, underscoring the need to consider fitness of future generations in pursuit of healthy ageing.
饮食限制（DR）可延长多种生物的寿命，并改善人类健康。然而，饮食干预的长期跨代后果却鲜为人知。在此，我们通过临时禁食（TF）研究了饮食限制对三代后代的死亡风险、特定年龄繁殖和适应性的影响。我们发现，虽然TF能有力地降低接受TF个体（P）的死亡风险并改善其晚年繁殖能力，但对其后代（F-F）却有广泛的正负两方面影响。值得注意的是，曾祖父母在生命早期经历TF会降低F代后代的适应性并增加其死亡风险，以至于TF不再能促进寿命延长。这些发现揭示了跨代权衡伴随着DR的即时益处，强调了在追求健康衰老时需要考虑后代的适应性。
