UMR CNRS/MNHN 7179, Mécanismes Adaptatifs et Evolution, 1 Avenue du Petit Château, 91800 Brunoy, France.
2Unité Mixte de Recherche en Santé 894 INSERM, Centre de Psychiatrie et Neurosciences, Université Paris Descartes, Sorbonne Paris Cité, 75014 Paris, France.
Commun Biol. 2019 Mar 15;2:107. doi: 10.1038/s42003-019-0348-z. eCollection 2019.
Recent data confirmed the efficiency of caloric restriction for promoting both healthspan and lifespan in primates, but also revealed potential adverse effects at the central level. This paper proposes perspectives and future directions to counterbalance potential adverse effects. Efforts should be made in combining nutrition-based clinical protocols with therapeutic and/or behavioral interventions to aim for synergetic effects, and therefore delay the onset of age-related diseases without adverse effects.
最近的数据证实了热量限制在促进灵长类动物健康寿命和寿命方面的有效性，但也揭示了中枢水平的潜在不良反应。本文提出了一些观点和未来的方向，以平衡潜在的不良反应。应该努力将基于营养的临床方案与治疗和/或行为干预相结合，以达到协同作用的效果，从而延迟与年龄相关的疾病的发作，而没有不良反应。
