Huang Kai, Sun Xiaoxin, Wu Haotian, Zhao Jun, Jian Yuli, Xu Zhongyang, Wang Shujing, Yang Deyong
Department of Urology, First Affifiliated Hospital of Dalian Medical University, Dalian, China.
College of Integrative Medicine, Dalian Medical University, Dalian, China.
J Oncol. 2021 Apr 22;2021:5510318. doi: 10.1155/2021/5510318. eCollection 2021.
Autophagy is a treatment target for many disorders, including cancer, and its specific role is becoming increasingly well known. In tumors, researchers pay attention to microribonucleic acids (miRNAs) with regulatory effects to develop more effective therapeutic drugs for autophagy and find new therapeutic targets. Various studies have shown that autophagy-related miRNAs play an irreplaceable role in different tumors, such as miR-495, miR-30, and miR-101. These miRNAs are associated with autophagy resistance in gastric cancer, non-small cell lung cancer, and cervical cancer. In recent years, autophagy-related miRNAs have also been reported to play a role in autophagy in urinary system tumors. This article reviews the regulatory effects of autophagy-related miRNAs in kidney, bladder, and prostate cancer and provides new ideas for targeted therapy of the three major tumors of the urinary system.
自噬是包括癌症在内的许多疾病的治疗靶点，其具体作用日益为人所知。在肿瘤中，研究人员关注具有调节作用的微小核糖核酸（miRNA），以开发更有效的自噬治疗药物并寻找新的治疗靶点。各种研究表明，自噬相关miRNA在不同肿瘤中发挥着不可替代的作用，如miR-495、miR-30和miR-101。这些miRNA与胃癌、非小细胞肺癌和宫颈癌中的自噬抗性有关。近年来，自噬相关miRNA也被报道在泌尿系统肿瘤的自噬中发挥作用。本文综述了自噬相关miRNA在肾癌、膀胱癌和前列腺癌中的调节作用，并为泌尿系统三大肿瘤的靶向治疗提供新思路。
