Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Center for Preclinical Research and Technology CEPT, Banacha 1B Str., Warsaw 02-097, Poland.
Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Center for Preclinical Research and Technology CEPT, Banacha 1B Str., Warsaw 02-097, Poland; Centro de Matemática, Computação e Cognição, Universidade Federal do ABC, Alameda da Universidade, s/n-Anchieta, São Paulo 09606-045, Brazil.
Cardiol Clin. 2020 Nov;38(4):601-617. doi: 10.1016/j.ccl.2020.07.005. Epub 2020 Sep 17.
Noncoding RNAs (ncRNAs), including long noncoding RNAs and microRNAs, play an important role in coronary artery disease onset and progression. The ability of ncRNAs to simultaneously regulate many target genes allows them to modulate various key processes involved in atherosclerosis, including lipid metabolism, smooth muscle cell proliferation, autophagy, and foam cell formation. This review focuses on the therapeutic potential of the most important ncRNAs in coronary artery disease. Moreover, various other promising microRNAs and long noncoding RNAs that attract substantial scientific interest as potential therapeutic targets in coronary artery disease and merit further investigation are presented.
非编码 RNA（ncRNA），包括长非编码 RNA 和 microRNA，在冠状动脉疾病的发生和发展中起着重要作用。ncRNA 能够同时调节许多靶基因，这使它们能够调节动脉粥样硬化过程中的各种关键过程，包括脂质代谢、平滑肌细胞增殖、自噬和泡沫细胞形成。本综述重点介绍了在冠状动脉疾病中最重要的 ncRNA 的治疗潜力。此外，还介绍了其他各种有前途的 microRNA 和长非编码 RNA，它们作为冠状动脉疾病潜在治疗靶点引起了广泛的科学关注，值得进一步研究。
