自噬在肿瘤发生中的作用。

Department of Pathological Cell Biology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.

Cancer Sci. 2020 Nov;111(11):3993-3999. doi: 10.1111/cas.14646. Epub 2020 Oct 1.

Various clinical and experimental findings have revealed the causal relationship between autophagy failure and oncogenesis, and several mechanisms have been suggested to explain this relationship. We recently proposed two additional mechanisms: centrosome number dysregulation and the failure of autophagic cell death. Here, we detail the mechanical relationship between autophagy failure and oncogenesis.

各种临床和实验发现揭示了自噬失败与肿瘤发生之间的因果关系，并且已经提出了几种解释这种关系的机制。我们最近提出了另外两种机制：中心体数量失调和自噬细胞死亡失败。在这里，我们详细描述了自噬失败与肿瘤发生之间的机械关系。