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Hsa_circ_0091581通过海绵化miR-1243-5p调控RMI1促进胶质瘤进展。

Hsa_circ_0091581 promotes glioma progression by regulating RMI1 via sponging miR-1243-5p.

作者信息

Qian Jin, Xu Yingna, Xu Xing, Tao Zhenyu, Luo Yang, Xu Yichang, Zhang Yong, Qian Chunfa

机构信息

Department of Neurosurgery, People's Hospital of Xuancheng City, Xuancheng, Anhui, China.

Department of Neurosurgery, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.

出版信息

J Cancer. 2021 Apr 2;12(11):3249-3256. doi: 10.7150/jca.55558. eCollection 2021.

DOI:10.7150/jca.55558
PMID:33976734
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8100801/
Abstract

Glioma is a pervasive malignancy and the main cause of cancer-related deaths worldwide. Circular RNA is an important subject of cancer research, and its role and function in glioma are poorly understood. This study demonstrated that hsa_circ_0091581 is upregulated in glioma tissues and cells. The results of the CCK-8, EdU, and transwell assays indicated that hsa_circ_0091581 promotes proliferation, migration, and invasion of glioma cells. The results of the luciferase reporter and RNA immunoprecipitation assays indicated that the mechanism of the effects of hsa_circ_0091581 on glioma cells involves sponging miR-1243-5p to regulate RMI1. The results of the rescue experiments indicated that hsa_circ_0091581 regulates proliferation, migration, and invasion of glioma cells by targeting RMI1 in a miR-1243-5p dependent manner. The results of the nude mice xenograft assays showed that knockdown of hsa_circ_0091581 inhibits glioma growth . Thus, our study determined the role of hsa_circ_0091581/miR-1243-5p/RMI1 in glioma and suggests that this axis may be a novel therapeutic target in glioma.

摘要

胶质瘤是一种普遍存在的恶性肿瘤，也是全球癌症相关死亡的主要原因。环状RNA是癌症研究的一个重要课题，但其在胶质瘤中的作用和功能尚不清楚。本研究表明，hsa_circ_0091581在胶质瘤组织和细胞中上调。CCK-8、EdU和transwell实验结果表明，hsa_circ_0091581促进胶质瘤细胞的增殖、迁移和侵袭。荧光素酶报告基因和RNA免疫沉淀实验结果表明，hsa_circ_0091581对胶质瘤细胞产生影响的机制涉及通过吸附miR-1243-5p来调节RMI1。拯救实验结果表明，hsa_circ_0091581通过以miR-1243-5p依赖的方式靶向RMI1来调节胶质瘤细胞的增殖、迁移和侵袭。裸鼠异种移植实验结果显示，敲低hsa_circ_0091581可抑制胶质瘤生长。因此，我们的研究确定了hsa_circ_0091581/miR-1243-5p/RMI1在胶质瘤中的作用，并表明该轴可能是胶质瘤的一个新的治疗靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c911/8100801/d6f377c1c055/jcav12p3249g006.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c911/8100801/c2352a1192dc/jcav12p3249g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c911/8100801/a57f9fef34df/jcav12p3249g004.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c911/8100801/d6f377c1c055/jcav12p3249g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c911/8100801/f9a75cc1dcc2/jcav12p3249g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c911/8100801/18a12ab4f8e2/jcav12p3249g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c911/8100801/c2352a1192dc/jcav12p3249g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c911/8100801/a57f9fef34df/jcav12p3249g004.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c911/8100801/d6f377c1c055/jcav12p3249g006.jpg

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