• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

黑色素瘤氧化应激相关预后风险模型的开发与验证

Development and validation of an oxidative stress-associated prognostic risk model for melanoma.

作者信息

Yang Yu, Long Xuan, Li Kun, Li Guiyun, Yu Xiaohong, Wen Ping, Luo Jun, Tian Xiaobin, Zhao Jinmin

机构信息

Department of Orthopedics Trauma and Hand Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.

Department of Obstetrics and Gynecology, The Affiliated Hospital of Guizhou Medical University, Guiyang, China.

出版信息

PeerJ. 2021 Apr 20;9:e11258. doi: 10.7717/peerj.11258. eCollection 2021.

DOI:10.7717/peerj.11258
PMID:33976978
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8063880/
Abstract

BACKGROUND

Oxidative stress (OS) is key to various diseases and is implicated in cancer progression and oncogenesis. However, the potential diagnostic value of OS-related genes in skin cutaneous melanoma (SKCM) remains unclear.

METHODS

We used data of RNA sequencing from 471 tumor tissues and one healthy tissue acquired from The Cancer Genome Atlas (TCGA)-SKCM cohort. The Genome Tissue Expression database was used to acquire transcriptome data from 812 healthy samples. OS-related genes that were differentially expressed between SKCM and healthy samples were investigated and 16 prognosis-associated OS genes were identified. The prognostic risk model was built using univariate and Cox multivariate regressions. The prognostic value of the hub genes was validated in the GSE65904 cohort, which included 214 SKCM patients.

RESULTS

The overall survival rate of SKCM patients in the high-risk group was decreased compared to the low-risk group. In both TCGA and GSE65904 cohorts, the ROC curves suggested that our prognostic risk model was more accurate than other clinicopathological characteristics to diagnose SKCM. Moreover, risk score and nomograms associated with the expression of hub genes were developed. These presented reiterated our prognostic risk model. Altogether, this study provides novel insights with regards to the pathogenesis of SKCM. The 16 hub genes identified may help in SKCM prognosis and individualized clinical treatment.

摘要

背景

氧化应激（OS）是多种疾病的关键因素，与癌症进展和肿瘤发生有关。然而，OS相关基因在皮肤黑色素瘤（SKCM）中的潜在诊断价值仍不清楚。

方法

我们使用了从癌症基因组图谱（TCGA）-SKCM队列中获取的471个肿瘤组织和1个健康组织的RNA测序数据。利用基因组组织表达数据库从812个健康样本中获取转录组数据。研究了SKCM与健康样本之间差异表达的OS相关基因，并鉴定了16个与预后相关的OS基因。使用单变量和Cox多变量回归建立预后风险模型。在包括214例SKCM患者的GSE65904队列中验证了枢纽基因的预后价值。

结果

与低风险组相比，高风险组SKCM患者的总生存率降低。在TCGA和GSE65904队列中，ROC曲线表明我们的预后风险模型在诊断SKCM方面比其他临床病理特征更准确。此外，还开发了与枢纽基因表达相关的风险评分和列线图。这些再次证明了我们的预后风险模型。总之，本研究为SKCM的发病机制提供了新的见解。所鉴定的16个枢纽基因可能有助于SKCM的预后和个体化临床治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ea3/8063880/8ca1257e234d/peerj-09-11258-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ea3/8063880/e2cabca76dad/peerj-09-11258-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ea3/8063880/c6e8a98b4671/peerj-09-11258-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ea3/8063880/71d6204f3893/peerj-09-11258-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ea3/8063880/709f9e092adc/peerj-09-11258-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ea3/8063880/c469bbba0a67/peerj-09-11258-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ea3/8063880/193bac1d345f/peerj-09-11258-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ea3/8063880/c13391c35bcb/peerj-09-11258-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ea3/8063880/1f82981da920/peerj-09-11258-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ea3/8063880/8ca1257e234d/peerj-09-11258-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ea3/8063880/e2cabca76dad/peerj-09-11258-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ea3/8063880/c6e8a98b4671/peerj-09-11258-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ea3/8063880/71d6204f3893/peerj-09-11258-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ea3/8063880/709f9e092adc/peerj-09-11258-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ea3/8063880/c469bbba0a67/peerj-09-11258-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ea3/8063880/193bac1d345f/peerj-09-11258-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ea3/8063880/c13391c35bcb/peerj-09-11258-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ea3/8063880/1f82981da920/peerj-09-11258-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ea3/8063880/8ca1257e234d/peerj-09-11258-g009.jpg

相似文献

1
Development and validation of an oxidative stress-associated prognostic risk model for melanoma.黑色素瘤氧化应激相关预后风险模型的开发与验证
PeerJ. 2021 Apr 20;9:e11258. doi: 10.7717/peerj.11258. eCollection 2021.
2
Identification of hub prognosis-associated oxidative stress genes in skin cutaneous melanoma using integrated bioinformatic analysis.基于整合生物信息学分析鉴定皮肤黑色素瘤中与预后相关的氧化应激枢纽基因
Eur Rev Med Pharmacol Sci. 2021 Apr;25(7):2927-2940. doi: 10.26355/eurrev_202104_25546.
3
Analysis on tumor immune microenvironment and construction of a prognosis model for immune-related skin cutaneous melanoma.肿瘤免疫微环境分析及免疫相关皮肤黑色素瘤预后模型的构建。
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2023 May 28;48(5):671-681. doi: 10.11817/j.issn.1672-7347.2023.230069.
4
The Landscape of the Tumor Microenvironment in Skin Cutaneous Melanoma Reveals a Prognostic and Immunotherapeutically Relevant Gene Signature.皮肤黑色素瘤肿瘤微环境全景揭示了一个与预后和免疫治疗相关的基因特征。
Front Cell Dev Biol. 2021 Oct 1;9:739594. doi: 10.3389/fcell.2021.739594. eCollection 2021.
5
System analysis based on the pyroptosis-related genes identifes GSDMD as a novel therapy target for skin cutaneous melanoma.基于细胞焦亡相关基因的系统分析鉴定 GSDMD 为皮肤黑色素瘤的一个新的治疗靶点。
J Transl Med. 2023 Nov 10;21(1):801. doi: 10.1186/s12967-023-04513-9.
6
Novel oxidative stress-related prognostic biomarkers for melanoma associated with tumor metastasis.新型与肿瘤转移相关的黑色素瘤氧化应激相关预后生物标志物。
Medicine (Baltimore). 2021 Feb 26;100(8):e24866. doi: 10.1097/MD.0000000000024866.
7
Development and validation of an immune gene set-based prognostic signature in cutaneous melanoma.基于免疫基因集的皮肤黑色素瘤预后标志物的开发和验证。
Future Oncol. 2021 Nov;17(31):4115-4129. doi: 10.2217/fon-2021-0104. Epub 2021 Jul 22.
8
Predicting the clinical outcome of melanoma using an immune-related gene pairs signature.利用免疫相关基因对signature 预测黑色素瘤的临床结局。
PLoS One. 2020 Oct 8;15(10):e0240331. doi: 10.1371/journal.pone.0240331. eCollection 2020.
9
Low expression of endoplasmic reticulum stress-related gene SERP1 is associated with poor prognosis and immune infiltration in skin cutaneous melanoma.内质网应激相关基因 SERP1 的低表达与皮肤黑色素瘤的不良预后和免疫浸润有关。
Aging (Albany NY). 2021 Oct 5;13(19):23036-23071. doi: 10.18632/aging.203594.
10
A Novel Necroptosis-Related Gene Signature in Skin Cutaneous Melanoma Prognosis and Tumor Microenvironment.一种用于皮肤黑色素瘤预后和肿瘤微环境的新型坏死性凋亡相关基因特征
Front Genet. 2022 Jul 11;13:917007. doi: 10.3389/fgene.2022.917007. eCollection 2022.

引用本文的文献

1
[Multi-omics analysis of the relationship between oxidative stress-related gene and prostate cancer].氧化应激相关基因与前列腺癌关系的多组学分析
Beijing Da Xue Xue Bao Yi Xue Ban. 2025 Aug 18;57(4):633-643. doi: 10.19723/j.issn.1671-167X.2025.04.002.
2
Identification and validation of oxidative stress-related genes in primary open-angle glaucoma by weighted gene co-expression network analysis and machine learning.基于加权基因共表达网络分析和机器学习鉴定及验证原发性开角型青光眼氧化应激相关基因。
Medicine (Baltimore). 2024 Nov 15;103(46):e40389. doi: 10.1097/MD.0000000000040389.
3
Identification of heterogeneous subtypes and a prognostic model for gliomas based on mitochondrial dysfunction and oxidative stress-related genes.

本文引用的文献

1
Upregulation of Enzymes involved in ISGylation and Ubiquitination in patients with hepatocellular carcinoma.肝细胞癌患者中参与 ISGylation 和泛素化的酶的上调。
Int J Med Sci. 2020 Jan 20;17(3):347-353. doi: 10.7150/ijms.39823. eCollection 2020.
2
Development and validation of a RNA binding protein-associated prognostic model for lung adenocarcinoma.肺腺癌 RNA 结合蛋白相关预后模型的建立与验证。
Aging (Albany NY). 2020 Feb 22;12(4):3558-3573. doi: 10.18632/aging.102828.
3
CCR5 status and metastatic progression in colorectal cancer.
基于线粒体功能障碍和氧化应激相关基因鉴定脑肿瘤的异质亚型和预后模型。
Front Immunol. 2023 Jun 2;14:1183475. doi: 10.3389/fimmu.2023.1183475. eCollection 2023.
4
The Effects of Oncological Treatment on Redox Balance in Patients with Uveal Melanoma.肿瘤治疗对葡萄膜黑色素瘤患者氧化还原平衡的影响。
Diagnostics (Basel). 2023 May 29;13(11):1907. doi: 10.3390/diagnostics13111907.
5
Establishment and external verification of an oxidative stress-related gene signature to predict clinical outcomes and therapeutic responses of colorectal cancer.用于预测结直肠癌临床结局和治疗反应的氧化应激相关基因特征的建立与外部验证
Front Pharmacol. 2023 Feb 13;13:991881. doi: 10.3389/fphar.2022.991881. eCollection 2022.
6
A Novel Necroptosis-Related Gene Signature in Skin Cutaneous Melanoma Prognosis and Tumor Microenvironment.一种用于皮肤黑色素瘤预后和肿瘤微环境的新型坏死性凋亡相关基因特征
Front Genet. 2022 Jul 11;13:917007. doi: 10.3389/fgene.2022.917007. eCollection 2022.
7
Genome-wide screening and immune landscape suggest a potential-m6A-related lncRNA risk signature for predicting prognosis of melanoma.全基因组筛查和免疫图谱提示一种潜在的与m6A相关的长链非编码RNA风险特征用于预测黑色素瘤的预后。
Ann Transl Med. 2022 Mar;10(5):241. doi: 10.21037/atm-21-4402.
CCR5 状态与结直肠癌的转移进展。
Oncoimmunology. 2019 Jul 13;8(9):e1626193. doi: 10.1080/2162402X.2019.1626193. eCollection 2019.
4
Oxidative Stress and Cancer.氧化应激与癌症。
Curr Pharm Des. 2018;24(40):4771-4778. doi: 10.2174/1381612825666190215121712.
5
Sirtuins and FoxOs in osteoporosis and osteoarthritis.Sirtuins 和 FoxOs 在骨质疏松症和骨关节炎中的作用。
Bone. 2019 Apr;121:284-292. doi: 10.1016/j.bone.2019.01.018. Epub 2019 Feb 6.
6
STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets.STRING v11：具有增强覆盖范围的蛋白质-蛋白质相互作用网络，支持在全基因组实验数据集的功能发现。
Nucleic Acids Res. 2019 Jan 8;47(D1):D607-D613. doi: 10.1093/nar/gky1131.
7
Guidelines of care for the management of primary cutaneous melanoma.原发性皮肤黑色素瘤治疗指南。
J Am Acad Dermatol. 2019 Jan;80(1):208-250. doi: 10.1016/j.jaad.2018.08.055. Epub 2018 Nov 1.
8
Metformin inhibited colitis and colitis-associated cancer (CAC) through protecting mitochondrial structures of colorectal epithelial cells in mice.二甲双胍通过保护结直肠上皮细胞的线粒体结构来抑制结肠炎和结肠炎相关癌症（CAC）。
Cancer Biol Ther. 2019;20(3):338-348. doi: 10.1080/15384047.2018.1529108. Epub 2018 Oct 25.
9
Oxidative stress and antioxidants in the pathophysiology of malignant melanoma.氧化应激与抗氧化剂在恶性黑色素瘤病理生理学中的作用
Biol Chem. 2019 Apr 24;400(5):589-612. doi: 10.1515/hsz-2018-0327.
10
Cervical Local Immune Response for High-Risk Human Papillomavirus Infection: Involvement With Cervical Mucus SLPI Proteins.高危型人乳头瘤病毒感染的宫颈局部免疫反应：与宫颈黏液分泌性白细胞蛋白酶抑制因子蛋白的关系
Cancer Control. 2018 Jan-Dec;25(1):1073274818798598. doi: 10.1177/1073274818798598.