Yasuoka Shotaro, Yuasa Takeshi, Fujiwara Motohiro, Fujisaki Junko, Inamura Kentaro, Komai Yoshinobu, Numao Noboru, Yamamoto Shinya, Yonese Junji
Department of Urology Cancer Institute Hospital Japanese Foundation for Cancer Research Tokyo Japan.
Department of Gastroenterological Medicine Cancer Institute Hospital Japanese Foundation for Cancer Research Tokyo Japan.
IJU Case Rep. 2021 Mar 10;4(3):136-138. doi: 10.1002/iju5.12261. eCollection 2021 May.
Metastatic renal cell carcinoma is treated with various regimens. As their outcomes are improving and follow-up periods are growing longer, the rate of unusual visceral metastases may increase.
A 68-year-old man diagnosed with lung, pancreatic, and renal metastases 9 years after left partial nephrectomy and a diagnosis of pT1a clear cell renal cell carcinoma started molecular targeted therapy using sunitinib. Nine years after the initiation of targeted therapy, a mass lesion in the esophagus was revealed by follow-up computed tomography, and endoscopic mucosal resection of the esophageal metastatic lesion was performed. One year later, a bladder tumor was detected by follow-up computed tomography. The patient underwent transurethral resection of the bladder tumor. Histological evaluation of both resected specimens disclosed clear cell renal cell carcinoma.
We present a valuable case of metachronous esophagus and bladder metastases from renal cell carcinoma in a long-term follow-up.
转移性肾细胞癌采用多种治疗方案。随着治疗效果的改善和随访期的延长，不常见的内脏转移率可能会增加。
一名68岁男性，在接受左肾部分切除术后9年被诊断为pT1a期透明细胞肾细胞癌，之后又被诊断出肺、胰腺和肾转移，开始使用舒尼替尼进行分子靶向治疗。靶向治疗开始9年后，随访计算机断层扫描发现食管有一个肿块病变，并对食管转移病变进行了内镜黏膜切除术。1年后，随访计算机断层扫描检测到膀胱肿瘤。患者接受了经尿道膀胱肿瘤切除术。对两个切除标本的组织学评估均显示为透明细胞肾细胞癌。
我们报告了一例在长期随访中肾细胞癌异时性食管和膀胱转移的有价值病例。
