Pastides H, Calabrese E J, Hosmer D W, Harris D R
Division of Public Health, University of Massachusetts, Amherst 01003.
J Occup Med. 1988 Jul;30(7):543-51.
The risk of adverse reproductive outcomes was examined among semiconductor manufacturers. Personal interviews were conducted with manufacturing workers, spouses of male manufacturers, and an internal comparison group of non-manufacturing workers. Elevated spontaneous abortion ratios were observed for females working in the "diffusion" (38.9%; relative risk = 2.18, 95% confidence interval estimate = 1.1, 3.6) and photolithographic process (31.1%; relative risk = 1.75, 95% confidence interval estimate = 0.8, 3.3). Analysis of potential confounding did not substantially alter the findings. The potential for recall bias was also assessed; although the confidence interval for the comparison of diffusion and non-manufacturing workers no longer excluded 1.0, an excess risk was still reflected. No substantive differences in other reproductive outcomes were identified. Various general health symptoms were examined and reported more frequently among manufacturers than non-exposed. These results should be viewed as tentative until studies with larger numbers and more detailed exposure data are carried out.
在半导体制造商中对不良生殖结局的风险进行了研究。对制造工人、男性制造商的配偶以及非制造工人的内部对照组进行了个人访谈。在从事“扩散”工序（38.9%；相对风险=2.18，95%置信区间估计=1.1，3.6）和光刻工序（31.1%；相对风险=1.75，95%置信区间估计=0.8，3.3）的女性中观察到自然流产率升高。对潜在混杂因素的分析并未实质性改变研究结果。还评估了回忆偏倚的可能性；尽管扩散工序工人与非制造工人比较的置信区间不再排除1.0，但仍反映出存在超额风险。未发现其他生殖结局有实质性差异。对各种一般健康症状进行了检查，结果显示制造商比未接触者报告得更频繁。在开展样本量更大、暴露数据更详细的研究之前，这些结果应视为初步结果。
