Kahramanmaras Sutcu Imam University School of Medicine, Department of Neurosurgery, Kahramanmaraş, Turkey.
Turk Neurosurg. 2021;31(4):594-600. doi: 10.5137/1019-5149.JTN.30907-20.1.
To investigate the effects of pregabalin on neural tube closure, and other potential effects on other organ systems in a chick embryo model.
Fertilized chicken eggs were divided into groups, and different doses of pregabalin was administered. All embryos were harvested in the 8th day of incubation, and investigated both macroscopically and microscopically against any developmental malformations caused by Pregabalin.
Macroscopically not any malformations were detected but macrosomia was statistically significant in medium and high dose groups. Microscopically, vertebral lamina ossification was delayed in some embryos in high dose group but not interpreted as midline closure defect and also not statistically significant. Decrease in the number of renal glomerulus and increase in the tubular damage was statistically significant in medium and high dose groups. Cardiomegaly was also found in some embryos in middle and high dose groups but not statistically significant.
The use of pregabalin does not cause neural tube closure defect in the embryo unless not exceed recommended maximum dose. Causing macrosomia instead of developmental retardation by Pregabalin is in conflict with the literature. This study revealed that Pregabalin causes fetal nephrotoxicity and macrosomia. These findings indicate that the use of Pregabalin in pregnancy still needs to be accounted as suspicious.
研究普瑞巴林对鸡胚神经管闭合的影响及其对其他器官系统的潜在影响。
将受精鸡蛋分为几组，并给予不同剂量的普瑞巴林。所有胚胎均在孵化第 8 天收获，对普瑞巴林引起的任何发育畸形进行宏观和微观检查。
宏观上未发现任何畸形，但中、高剂量组的巨体发生具有统计学意义。微观上，高剂量组部分胚胎的椎板骨化延迟，但不能解释为中线闭合缺陷，且无统计学意义。中、高剂量组的肾小球数量减少和肾小管损伤增加具有统计学意义。中、高剂量组的一些胚胎也有心肥大，但无统计学意义。
普瑞巴林的使用不会导致胚胎神经管闭合缺陷，除非超过推荐的最大剂量。普瑞巴林引起的巨体发生而不是发育迟缓与文献相矛盾。本研究表明普瑞巴林可导致胎儿肾毒性和巨体发生。这些发现表明，普瑞巴林在妊娠期间的使用仍需谨慎考虑。
