Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA.
Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.
J Exp Med. 2021 Jul 5;218(7). doi: 10.1084/jem.20210572. Epub 2021 May 12.
In this issue, Le Coz et al. (2021. J. Exp. Med.https://doi.org/10.1084/jem.20201750) describe a novel immunodeficiency syndrome caused by mutations in SPI1. Through a series of in-depth studies, the authors provide insights into how SPI1 affects blood lineage specification, highlighting the important role of master transcription factors as cellular fate determinants.
本期杂志中，Le Coz 等人（2021，《实验医学杂志》，https://doi.org/10.1084/jem.20201750）描述了一种由 SPI1 基因突变引起的新型免疫缺陷综合征。通过一系列深入研究，作者深入了解了 SPI1 如何影响血液谱系特化，强调了主转录因子作为细胞命运决定因素的重要作用。
