Mucosal Immunology Group, Department of Pediatrics, Rostock University Medical Center, Ernst-Heydemann-Str. 8, 18057, Rostock, Germany.
Department of Systems Biology and Bioinformatics, University of Rostock, Universitätsplatz 1, 18055, Rostock, Germany.
Clin Epigenetics. 2021 May 12;13(1):108. doi: 10.1186/s13148-021-01089-3.
Epigenetics has become a promising field for finding new biomarkers and improving diagnosis, prognosis, and drug response in inflammatory bowel disease. The number of people suffering from inflammatory bowel diseases, especially Crohn's disease, has increased remarkably. Crohn's disease is assumed to be the result of a complex interplay between genetic susceptibility, environmental factors, and altered intestinal microbiota, leading to dysregulation of the innate and adaptive immune response. While many genetic variants have been identified to be associated with Crohn's disease, less is known about the influence of epigenetics in the pathogenesis of this disease. In this review, we provide an overview of current epigenetic studies in Crohn's disease. In particular, we enable a deeper insight into applied bioanalytical and computational tools, as well as a comprehensive update toward the cell-specific evaluation of DNA methylation and histone modifications.
表观遗传学已成为一个有前途的领域，可以发现新的生物标志物，并改善炎症性肠病的诊断、预后和药物反应。患炎症性肠病（尤其是克罗恩病）的人数显著增加。据推测，克罗恩病是遗传易感性、环境因素和肠道微生物群改变之间复杂相互作用的结果，导致先天和适应性免疫反应失调。虽然已经确定了许多与克罗恩病相关的遗传变异，但对于表观遗传学在这种疾病发病机制中的影响知之甚少。在这篇综述中，我们概述了克罗恩病的当前表观遗传学研究。特别是，我们深入了解了应用生物分析和计算工具，并全面更新了针对 DNA 甲基化和组蛋白修饰的细胞特异性评估。
