Xie Bumin, Guo Yuan
Department of Obstetrics and Gynecology, Key Laboratory for Major Obstetric Diseases of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, China.
Cell Death Discov. 2021 May 12;7(1):101. doi: 10.1038/s41420-021-00483-3.
Ferroptosis is a newly identified form of nonapoptotic regulated cell death characterized by iron-dependent accumulation of lipid reactive oxygen species. Morphologically and biochemically different from known types of cell death and apoptosis, ferroptosis promotes nervous system diseases, renal failure, ischemia-reperfusion injury, and the treatment of tumors. It could be induced by several mechanisms, including inhibition of glutathione peroxidase 4, lack of cysteine, and peroxidation of polyunsaturated fatty acids, but could be inhibited by iron chelators, lipophilic antioxidants, and some specific inhibitors. Ferroptosis is found to be closely related to the tumorigenesis, invasion, and metastasis of tumors. Noncoding RNAs (ncRNAs), including long noncoding RNAs (lncRNAs), microRNAs, and circular RNAs, do not encode proteins. NcRNAs are found to be capable of regulating the molecular mechanism of ferroptosis in tumor cells post transcription. Ferroptosis provides a new method for cancer treatment. Although several studies have confirmed the important role of ferroptosis in cancer treatment, its specific affecting mechanism is unclear. Here we reviewed the molecular mechanism of ferroptosis in tumor cells and the relationship between ferroptosis and the three important ncRNAs.
铁死亡是一种新发现的非凋亡性调节性细胞死亡形式，其特征是脂质活性氧的铁依赖性积累。在形态学和生物化学上与已知类型的细胞死亡和凋亡不同，铁死亡会引发神经系统疾病、肾衰竭、缺血再灌注损伤以及肿瘤治疗。它可由多种机制诱导，包括谷胱甘肽过氧化物酶4的抑制、半胱氨酸缺乏以及多不饱和脂肪酸的过氧化，但可被铁螯合剂、亲脂性抗氧化剂和一些特定抑制剂抑制。研究发现铁死亡与肿瘤的发生、侵袭和转移密切相关。非编码RNA（ncRNA），包括长链非编码RNA（lncRNA）、微小RNA和环状RNA，不编码蛋白质。发现ncRNA能够在转录后调节肿瘤细胞中铁死亡的分子机制。铁死亡为癌症治疗提供了一种新方法。尽管多项研究证实了铁死亡在癌症治疗中的重要作用，但其具体影响机制尚不清楚。在此，我们综述了肿瘤细胞中铁死亡的分子机制以及铁死亡与三种重要ncRNA之间的关系。
