Senarat Setthapong, Wai Lwin Wai, Mahadlek Jongjan, Phaechamud Thawatchai
Programe of Pharmaceutical Engineering, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom 73000, Thailand.
Department of Pharmaceutical Technology, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom 73000, Thailand.
Saudi Pharm J. 2021 Mar;29(3):252-263. doi: 10.1016/j.jsps.2021.01.009. Epub 2021 Feb 10.
Polymeric material plays an important role as a matrix former in the modulation of drug release of antimicrobial-loaded forming gel (ISG) for efficient periodontitis treatment. This study was conducted to compare three polymers, namely bleached shellac (BS), Ethocel (EC) and Eudragit RS (ERS), as matrix formers of doxycycline hyclate (DH)-loaded solvent exchange-induced ISG. All prepared ISGs, except 25% EC ISG, exhibited the Newtonian flow behaviour. Transformation from solution into matrix-like was achieved rapidly within 5 min. Increasing the amount of these polymers extended the release of DH. DH-loaded EC and ERS ISG systems exhibited high antimicrobial activity, and all ISGs were effective in inhibiting the growth of , , , and . By comparison, the DH-loaded ERS ISG, through the solvent exchange mechanism, was found to be ease in injection with low viscosity and sustained the release with higher concentration, meanwhile, it also exhibited interesting degradability and antimicrobial activities. Therefore, the DH-loaded ERS ISG exhibited a potential use for localized periodontal drug delivery system for the treatment periodontitis.
高分子材料作为基质形成剂，在调节载有抗菌药物的成胶溶液（ISG）的药物释放以有效治疗牙周炎方面发挥着重要作用。本研究旨在比较三种聚合物，即漂白紫胶（BS）、乙基纤维素（EC）和聚丙烯酸树脂RS（ERS），作为载有盐酸多西环素（DH）的溶剂交换诱导型ISG的基质形成剂。除25% EC ISG外，所有制备的ISG均表现出牛顿流体行为。在5分钟内迅速实现了从溶液到基质状的转变。增加这些聚合物的用量可延长DH的释放时间。载有DH的EC和ERS ISG系统表现出高抗菌活性，且所有ISG均能有效抑制牙龈卟啉单胞菌、福赛坦氏菌、具核梭杆菌、中间普氏菌和变黑普氏菌的生长。相比之下，载有DH的ERS ISG通过溶剂交换机制，发现易于注射且粘度低，并能以较高浓度持续释放，同时，它还表现出有趣的降解性和抗菌活性。因此，载有DH的ERS ISG在治疗牙周炎的局部牙周药物递送系统中具有潜在用途。
