Fagerberg Peter S, Ramberg Ingvild M S, Toft Peter B
Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
Department of Pathology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
Ocul Oncol Pathol. 2021 Mar;7(2):77-84. doi: 10.1159/000512029. Epub 2021 Jan 11.
Separately, cryotherapy and brachytherapy have shown promising results when adjuvating the excision of squamous cell carcinoma of the conjunctiva (SCCC). The aim of this paper is to assess the combined effect in terms of complications and recurrence rate.
We describe 2 patients suffering from SCCC, and we review the current literature on adjuvant cryotherapy and brachytherapy. Both patients, one of whom suffered from recurrent SCCC, underwent surgical excision followed by combined cryotherapy and brachytherapy. Cryotherapy was performed using a retinal cryoprobe, and 2 rounds each of 5 s with NO as a cryogen were applied. Brachytherapy was performed using a ruthenium-106 plaque, delivering a dosage of 100 Gy at 2-mm depth.
By reviewing the current literature and describing 2 case reports, this paper illustrates the use of combined cryotherapy and brachytherapy after surgical excision of SCCC. The current literature presents promising results of each treatment, and the 2 cases showed promising results by combining the 2 adjuvant therapies showing no signs of recurrence or complications during a follow-up period of 26 and 38 months.
单独使用冷冻疗法和近距离放射疗法在辅助结膜鳞状细胞癌（SCCC）切除时已显示出有前景的结果。本文的目的是评估在并发症和复发率方面的联合效果。
我们描述了2例患有SCCC的患者，并回顾了当前关于辅助冷冻疗法和近距离放射疗法的文献。两名患者，其中一名患有复发性SCCC，均接受了手术切除，随后进行了冷冻疗法和近距离放射疗法联合治疗。使用视网膜冷冻探头进行冷冻疗法，以一氧化二氮作为制冷剂，每次5秒，共进行2轮。使用钌-106敷贴器进行近距离放射疗法，在2毫米深度处给予100戈瑞的剂量。
通过回顾当前文献并描述2例病例报告，本文阐述了SCCC手术切除后联合使用冷冻疗法和近距离放射疗法的情况。当前文献显示每种治疗方法都有前景的结果，这2例病例通过联合两种辅助疗法也显示出有前景的结果，在26个月和38个月的随访期内未出现复发或并发症迹象。
