Department of Organ Anatomy, Tohoku University Graduate School of Medicine, Sendai, Japan.
FEBS Lett. 2021 Jul;595(13):1797-1805. doi: 10.1002/1873-3468.14106. Epub 2021 May 25.
Fatty acid-binding protein (FABP) 5 is highly expressed in various types of tumors and is strongly correlated with tumor growth, development, and metastasis. However, it is unclear how the expression of FABP5 in the host affects tumor progression. In this study, using a lung tumor metastasis model in mice, we found that FABP5-deficient mice were more susceptible to tumor metastasis, which is accompanied by infiltration of a lower frequency of activated natural killer (NK) cells in the lung. Additionally, FABP5 deficiency leads to impaired maturation of NK cells in the lungs, but not in the bone marrow and spleen. Taken together, our results provide the first evidence that FABP5 in the host regulates lung tumor metastasis through controlling NK cell maturation.
脂肪酸结合蛋白 5（FABP5）在多种类型的肿瘤中高度表达，与肿瘤的生长、发展和转移密切相关。然而，宿主中 FABP5 的表达如何影响肿瘤的进展尚不清楚。在本研究中，我们利用小鼠的肺肿瘤转移模型发现，FABP5 缺陷小鼠更容易发生肿瘤转移，这伴随着肺中浸润的活化自然杀伤（NK）细胞频率降低。此外，FABP5 缺陷导致 NK 细胞在肺部而非骨髓和脾脏中的成熟受损。综上所述，我们的研究结果首次提供了证据表明，宿主中的 FABP5 通过控制 NK 细胞的成熟来调节肺肿瘤转移。
