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肺癌中的代谢重编程及其临床意义。

Metabolic reprogramming in lung cancer and its clinical implication.

作者信息

Huang Qingqiu, Fan Lisha, Gong Mingjing, Ren Juntong, Chen Chen, Xie Shenglong

机构信息

Department of Thoracic Surgery, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.

Department of Pulmonary and Critical Care Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.

出版信息

Front Pharmacol. 2024 Dec 18;15:1516650. doi: 10.3389/fphar.2024.1516650. eCollection 2024.

Abstract

Lung cancer has posed a significant challenge to global health, and related study has been a hot topic in oncology. This article focuses on metabolic reprogramming of lung cancer cells, a process to adapt to energy demands and biosynthetic needs, supporting the proliferation and development of tumor cells. In this study, the latest studies on lung cancer tumor metabolism were reviewed, including the impact of metabolic products and metabolic enzymes on the occurrence and development of lung cancer, as well as the progress in the field of lung cancer treatment targeting relevant metabolic pathways. This provides some promising potential directions into exploring lung cancer tumor metabolism and helps researchers to better understand lung cancer.

摘要

肺癌对全球健康构成了重大挑战,相关研究一直是肿瘤学领域的热点话题。本文聚焦于肺癌细胞的代谢重编程,这是一个适应能量需求和生物合成需求以支持肿瘤细胞增殖和发展的过程。在本研究中,对肺癌肿瘤代谢的最新研究进行了综述,包括代谢产物和代谢酶对肺癌发生发展的影响,以及针对相关代谢途径的肺癌治疗领域的进展。这为探索肺癌肿瘤代谢提供了一些有前景的潜在方向,并有助于研究人员更好地理解肺癌。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89d0/11688361/9c276eca060e/fphar-15-1516650-g001.jpg

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