State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Ningbo University, Ningbo, China.
Vigor Technology Group, Shenzhen, China.
Food Funct. 2021 Jun 21;12(12):5387-5398. doi: 10.1039/d1fo00709b.
Rheumatoid arthritis is emerging as a chronic autoimmune disease worldwide. In this study, the beneficial effects of tuna oil (TO) on collagen-induced arthritis (CIA) mice were investigated. Dietary administration of TO relieved arthritis severity and joint bone erosion, and ameliorated systemic inflammation. Furthermore, TO treatments regulated the phosphorylation of nuclear factor-kappa B (NF-κB) and Wnt1/β-catenin signaling pathways in the joint, enhanced osteoblastogenesis biomarkers and suppressed osteoclastogenesis biomarkers, and subsequently re-balanced bone remodeling. Moreover, the impaired intestinal epithelial barrier was repaired after TO treatments, along with gut microbiota modulation. By employing fecal microbiota transplantation, we clarified that the beneficial effects of TO in CIA alleviation were mediated by the modulated gut microbiota. These results indicated that gut microbiota mediated the protective effects of tuna oil on collagen-induced arthritis in mice.
类风湿关节炎在全球范围内正逐渐成为一种慢性自身免疫性疾病。在这项研究中，研究了金枪鱼油（TO）对胶原诱导性关节炎（CIA）小鼠的有益作用。饮食中添加 TO 可缓解关节炎严重程度和关节骨侵蚀，并改善全身炎症。此外，TO 治疗还调节了关节中核因子-κB（NF-κB）和 Wnt1/β-连环蛋白信号通路的磷酸化，增强了成骨细胞生物标志物的表达，抑制了破骨细胞生物标志物的表达，从而重新平衡了骨重塑。此外，TO 治疗后修复了受损的肠道上皮屏障，并调节了肠道微生物群。通过粪便微生物群移植，我们阐明了 TO 在 CIA 缓解中的有益作用是通过调节肠道微生物群介导的。这些结果表明，肠道微生物群介导了金枪鱼油对胶原诱导性关节炎小鼠的保护作用。
