Kotlyar Michael, Shanley Ryan, Dufresne Sheena R, Corcoran Gretchen A, Okuyemi Kolawole S, Mills Anne M, Hatsukami Dorothy K
Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN, USA.
Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA.
Nicotine Tob Res. 2021 Oct 7;23(11):1921-1927. doi: 10.1093/ntr/ntab090.
Bans of menthol characterizing flavor in cigarettes have been implemented in some localities and have been proposed more broadly. One proposed benefit of such a ban is to increase cessation rates among current menthol smokers. There is currently relatively limited data regarding how smoking behavior changes if menthol smokers switch to non-menthol cigarettes.
African American menthol smokers interested in quitting smoking were randomized to either continue smoking menthol (n = 60) or switch to non-menthol cigarettes (n = 62) for 1 month prior to a cessation attempt. Cessation results were reported previously; this analysis reports the results from the pre-cessation visits at which amount smoked, exhaled carbon monoxide (CO) concentration, urinary cotinine concentrations, and subjective measures were assessed.
Over the 4-week study period, those switching to non-menthol (vs. continuing to smoke menthol) cigarettes smoked fewer cigarettes per day (mean ratio: 0.86; 95% confidence interval [CI]: 0.76, 0.98; p = .02), reported lower withdrawal symptom severity (mean difference -1.29; 95% CI: -2.6 to -0.01; p = .05) and higher perceived effectiveness of their skills for quitting smoking (mean difference 0.56; 95% CI: 0.02-1.10; p = .05). No significant differences were found between groups in exhaled CO, urinary cotinine concentrations, or most other subjective effects including support for a ban on menthol characterizing flavor in cigarettes.
These results suggest that were menthol cigarettes no longer available, those that switch to non-menthol cigarettes would not change their smoking behavior in a way that is likely to be more hazardous, with some indicators suggesting that there may be some benefit.Clinicaltrials.gov # NCT02342327.
A ban on menthol characterizing flavor in cigarettes has been proposed as a potential means by which to increase smoking cessation rates among current menthol cigarette smokers. This study evaluated how African American menthol cigarette smokers adjusted their smoking behavior after switching to non-menthol cigarettes. Although the overall differences between groups were modest, they were in a direction consistent with decreased smoking suggesting that current smokers would not adjust their behavior in a way that is likely to be more hazardous, with some indicators suggesting that there may be some benefits.
一些地区已实施禁止香烟中具有薄荷醇特征风味的规定,并且更广泛地提出了此类禁令。这种禁令的一个预期好处是提高当前薄荷醇吸烟者的戒烟率。目前,关于薄荷醇吸烟者转而吸食非薄荷醇香烟后吸烟行为如何变化的数据相对有限。
有戒烟意愿的非裔美国薄荷醇吸烟者被随机分为两组,一组在尝试戒烟前1个月继续吸食薄荷醇香烟(n = 60),另一组转而吸食非薄荷醇香烟(n = 62)。先前已报告了戒烟结果;本分析报告了戒烟前访视的结果,在访视中评估了吸烟量、呼出一氧化碳(CO)浓度、尿可替宁浓度和主观指标。
在为期4周的研究期间,转而吸食非薄荷醇香烟(与继续吸食薄荷醇香烟相比)的人每天吸烟量更少(平均比率:0.86;95%置信区间[CI]:0.76,0.98;p = 0.02),报告的戒断症状严重程度更低(平均差异 -1.29;95% CI:-2.6至-0.01;p = 0.05),且认为自己戒烟技能的有效性更高(平均差异0.56;95% CI:0.02 - 1.10;p = 0.05)。两组在呼出CO、尿可替宁浓度或包括支持禁止香烟中具有薄荷醇特征风味在内的大多数其他主观影响方面未发现显著差异。
这些结果表明,如果不再有薄荷醇香烟,转而吸食非薄荷醇香烟的人不会以可能更有害的方式改变其吸烟行为,一些指标表明可能会有一些益处。Clinicaltrials.gov # NCT02342327。
已提议禁止香烟中具有薄荷醇特征风味,作为提高当前薄荷醇吸烟者戒烟率的一种潜在手段。本研究评估了非裔美国薄荷醇吸烟者转而吸食非薄荷醇香烟后如何调整其吸烟行为。尽管两组之间的总体差异不大,但方向与吸烟减少一致,表明当前吸烟者不会以可能更有害的方式调整其行为,一些指标表明可能会有一些益处。