Section of Pharmacognosy and Chemistry of Natural Products, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, Athens 15771, Greece.
Laboratory of Biotechnology, School of Chemical Engineering, National Technical University of Athens, 9 Iroon Polytechniou Str., Zografou Campus, Athens 15780, Greece.
Mar Drugs. 2017 Dec 14;15(12):389. doi: 10.3390/md15120389.
Four new (-) and six previously reported (-) α-pyrone polyketides, along with benzoic acid, hydrocinnamic acid, and ()-cinnamic acid, were isolated from the organic extract resulting from the cultivation of the algicolous strain BI0048, which in turn was isolated from the inner tissues of the red alga . The structure elucidation of the isolated natural products was based on extensive analysis of their spectroscopic data (NMR, MS, UV, IR). Compounds - were evaluated for their antibacterial and cytotoxic activities against two multidrug-resistant strains of and one strain of , as well as two human cancer cell lines.
从藻类 BI0048 的有机提取物中分离得到了四种新的（-）和六种先前报道的（-）α-吡喃酮聚酮化合物，以及苯甲酸、肉桂酸和（）-肉桂酸。BI0048 是从红藻的内部组织中分离出来的。通过对分离得到的天然产物的光谱数据（NMR、MS、UV、IR）进行广泛分析，确定了它们的结构。对化合物-进行了抗菌和细胞毒性活性评价，测试了它们对两种多药耐药菌株和一种菌株以及两种人癌细胞系的作用。
