DZNE - Deutsches Zentrum für Neurodegenerative Erkrankungen, Rostock-Greifswald site, Rostock, Germany.
LANVIE - Laboratory of Neuroimaging of Aging, University of Geneva, Geneva, Switzerland.
Alzheimers Dement. 2022 Jan;18(1):29-42. doi: 10.1002/alz.12365. Epub 2021 May 13.
Harmonized neuropsychological assessment for neurocognitive disorders, an international priority for valid and reliable diagnostic procedures, has been achieved only in specific countries or research contexts.
To harmonize the assessment of mild cognitive impairment in Europe, a workshop (Geneva, May 2018) convened stakeholders, methodologists, academic, and non-academic clinicians and experts from European, US, and Australian harmonization initiatives.
With formal presentations and thematic working-groups we defined a standard battery consistent with the U.S. Uniform DataSet, version 3, and homogeneous methodology to obtain consistent normative data across tests and languages. Adaptations consist of including two tests specific to typical Alzheimer's disease and behavioral variant frontotemporal dementia. The methodology for harmonized normative data includes consensus definition of cognitively normal controls, classification of confounding factors (age, sex, and education), and calculation of minimum sample sizes.
This expert consensus allows harmonizing the diagnosis of neurocognitive disorders across European countries and possibly beyond.
协调神经认知障碍的神经心理学评估是一个国际优先事项，需要有效的和可靠的诊断程序，但目前仅在特定国家或研究环境中实现。
为了在欧洲协调轻度认知障碍的评估，一个研讨会（2018 年 5 月，日内瓦）召集了利益相关者、方法学家、学术和非学术临床医生以及来自欧洲、美国和澳大利亚协调倡议的专家。
通过正式的演示和专题工作组，我们定义了一个与美国统一数据集版本 3 一致的标准电池，并采用了一致的方法，以在测试和语言之间获得一致的规范数据。适应包括纳入两种特定于典型阿尔茨海默病和行为变异额颞叶痴呆的测试。协调规范数据的方法包括对认知正常对照的共识定义、混杂因素（年龄、性别和教育）的分类以及最小样本量的计算。
这一专家共识使得在欧洲国家乃至更广泛的范围内协调神经认知障碍的诊断成为可能。
