Matías-Guiu Jordi A, Curiel Rosie E, Rognoni Teresa, Valles-Salgado María, Fernández-Matarrubia Marta, Hariramani Roshan, Fernández-Castro Alejandro, Moreno-Ramos Teresa, Loewenstein David A, Matías-Guiu Jorge
Department of Neurology, San Carlos Institute for Health Research (IdISSC), Universidad Complutense, Madrid, Spain.
Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami and Center of Aging, Miami, FL, USA.
J Alzheimers Dis. 2017;56(2):733-742. doi: 10.3233/JAD-160866.
The Loewenstein-Acevedo Scale for Semantic Interference and Learning (LASSI-L) is a novel cognitive test that measures recovery from proactive semantic interference, which may be an early cognitive marker of Alzheimer's disease (AD).
To generate normative data for a Spaniard population and to validate the LASSI-L for the diagnosis of amnestic mild cognitive impairment (aMCI) and mild AD.
We performed a cross-sectional study in which 97 healthy participants, 34 with aMCI, and 33 with mild AD were studied with LASSI-L and a comprehensive neuropsychological protocol. The overlapping strategy analysis was used to maximize the sample size and to provide age- and education-adjusted normative data using a logistic regression analysis.
Internal consistency was 0.932. Convergent validity with the Free and Cued Selective Reminding Test was moderate. LASSI-L raw scores were correlated with age and years of education, but not gender. The area under the curve for discriminating between healthy controls and aMCI was 0.909, and between healthy controls and mild AD was 0.986. LASSI-L sub-scores representing maximum storage capacity, recovery from proactive interference, and delayed recall yielded the highest diagnostic accuracy.
The LASSI-L is a reliable and valid test for the diagnosis of aMCI and mild AD. The age and education influences on the performance of the test and normative data are provided. LASSI-L merits further studies to evaluate its ability to detect preclinical AD and predict progression to aMCI and early dementia.
洛温斯坦 - 阿塞维多语义干扰与学习量表（LASSI - L）是一种新型认知测试，用于测量从主动语义干扰中恢复的情况，这可能是阿尔茨海默病（AD）的早期认知标志物。
为西班牙人群生成常模数据，并验证LASSI - L用于诊断遗忘型轻度认知障碍（aMCI）和轻度AD的有效性。
我们进行了一项横断面研究，对97名健康参与者、34名aMCI患者和33名轻度AD患者进行了LASSI - L测试及全面的神经心理学评估。采用重叠策略分析以最大化样本量，并使用逻辑回归分析提供年龄和教育程度调整后的常模数据。
内部一致性为0.932。与自由和提示选择性回忆测试的聚合效度中等。LASSI - L原始分数与年龄和受教育年限相关，但与性别无关。区分健康对照和aMCI的曲线下面积为0.909，区分健康对照和轻度AD的曲线下面积为0.986。代表最大存储容量、从主动干扰中恢复以及延迟回忆的LASSI - L子分数产生了最高的诊断准确性。
LASSI - L是诊断aMCI和轻度AD的可靠且有效的测试。提供了年龄和教育程度对测试表现的影响以及常模数据。LASSI - L值得进一步研究以评估其检测临床前AD以及预测进展为aMCI和早期痴呆的能力。
