Faculdade Evangélica Mackenzie de Medicina, Curitiba, PR, Brazil.
Trends Psychiatry Psychother. 2022 Aug 31;44:e20210251. doi: 10.47626/2237-6089-2021-0251.
Adverse childhood experiences (ACEs) have been linked to occurrence of autoimmune diseases in adults, including psoriasis.
To study the prevalence of ACEs in psoriasis patients, comparing them with a sample from the general population.
Three hundred and eighteen individuals were included (104 psoriasis patients and 214 controls). Patients and controls answered questions on an ACE study questionnaire about experiences of childhood abuse, negligence, domestic violence, and household dysfunction. Questionnaire scores range from zero (best result) to 8 (worst scenario). Psoriasis patients' charts were reviewed for epidemiological, clinical, and treatment data. A Psoriasis Area Severity Index (PASI) was calculated from measurements taken when the questionnaire was administered.
Psoriasis patients reported a median of 4 ACEs (interquartile range [IQR] = 3-5) while controls had a median of 3 (IQR = 2-4) with p < 0.0001. The number of ACEs was not associated with PASI, age of disease onset, or presence of associated arthritis (all p > 0.5). Female psoriasis patients had more ACEs than males (p = 0.04).
Patients with psoriasis have more ACEs than controls and ACEs were more common in female patients.
不良的童年经历（ACEs）与成年人自身免疫性疾病的发生有关，包括银屑病。
研究银屑病患者 ACEs 的患病率，并将其与一般人群样本进行比较。
共纳入 318 名参与者（104 名银屑病患者和 214 名对照者）。患者和对照者回答了 ACE 研究问卷中关于童年虐待、忽视、家庭暴力和家庭功能障碍经历的问题。问卷评分范围从 0（最佳结果）到 8（最差情况）。回顾银屑病患者的病历以获取流行病学、临床和治疗数据。在进行问卷调查时，根据测量结果计算出银屑病面积严重程度指数（PASI）。
银屑病患者报告的 ACEs 中位数为 4 项（四分位距 [IQR] = 3-5），而对照组的 ACEs 中位数为 3 项（IQR = 2-4），p<0.0001。ACEs 的数量与 PASI、疾病发病年龄或是否存在相关关节炎均无关（均 p>0.5）。女性银屑病患者的 ACEs 比男性多（p=0.04）。
银屑病患者的 ACEs 比对照组多，且女性患者中 ACEs 更为常见。
