Key Laboratory for Animal Genetics & Molecular Breeding of Jiangsu Province, College of Animal Science and Technology, Yangzhou University, Yangzhou, 225009, China.
Toxicology. 2021 Jun 15;457:152810. doi: 10.1016/j.tox.2021.152810. Epub 2021 May 10.
With the rapid development of economic globalization and industrialization, lead (Pb), one of the most important heavy metals, has been used widely since antiquity for several purposes. In fact, its impact on the health of animals and humans is a significant public health risk all the time. Pb could be accumulated in the body for a long time, causing irreversible damage to the health of animals and humans, including hostile reproductive health. Up to now, although there are some published studies on impeding the normal development of ovarian folliculogenesis of female resulted from Pb exposure, with the damage of structure in uterine tissue, the imbalance of female menstrual status, and the change of hormone levels. The potential mechanism of Pb exposure on female reproduction system, however, remains enigmatic. How to alleviate the damage of Pb toxicity to reproductive function of female has become an urgent problem. Therefore, the aim of the present review is to discuss the information on the growth and development of ovarian follicle of mammalians and the potential toxic mechanism when exposed to Pb. The literatures were collected via various websites and consulting books, reports, etc. In summary, Pb impair folliculogenesis of mammalians, which may be related to the interference to the hypothalamic-pituitary-gonadal (HPG) axis and the production of reactive oxygen species (ROS), in turn impairs various molecules including proteins, lipids and DNA, as well as the disruption of the antioxidant defense system, ionic equilibrium and endoplasmic reticulum homeostasis.
随着经济全球化和工业化的快速发展，铅（Pb）作为最重要的重金属之一，自古以来就被广泛应用于多种用途。事实上，它对动物和人类健康的影响一直是一个重大的公共卫生风险。Pb 可以在体内长时间积累，对动物和人类的健康造成不可逆转的损害，包括生殖健康受损。到目前为止，虽然有一些关于 Pb 暴露阻碍女性卵巢卵泡发生正常发育的研究，包括对子宫组织结构的损害、女性月经状态的失衡和激素水平的变化。然而，Pb 暴露对女性生殖系统的潜在机制仍然是个谜。如何减轻 Pb 毒性对女性生殖功能的损害已成为一个紧迫的问题。因此，本综述的目的是讨论哺乳动物卵巢卵泡生长和发育的信息，以及 Pb 暴露时的潜在毒性机制。通过各种网站收集文献，并查阅书籍、报告等。总之，Pb 损害哺乳动物的卵泡发生，这可能与下丘脑-垂体-性腺（HPG）轴的干扰和活性氧（ROS）的产生有关，进而损害包括蛋白质、脂质和 DNA 在内的各种分子，以及破坏抗氧化防御系统、离子平衡和内质网稳态。
