Laboratory of Biodiversity, Ecology, and Genome, Faculty of Sciences, Mohammed V University in Rabat, Morocco.
Laboratory of Histology, Embryology, And Cytogenetic, Faculty of Medicine and Pharmacy, Mohammed V University in Rabat, Morocco.
Food Chem Toxicol. 2021 Jul;153:112259. doi: 10.1016/j.fct.2021.112259. Epub 2021 May 11.
p-cymene also known as p-cymol or p-isopropyltoluene is an alkyl-substituted aromatic compound naturally occurring in essential oils (EOs) of various aromatic plants, including the genus of Artemisia, Protium, Origanum, and Thymus. It is related to the family of terpenes, especially monocyclic monoterpenes. p-cymene is also present in several food-based plants such as carrots, orange juice, grapefruit, tangerine, raspberries and several spices. Numerous studies have demonstrated the pharmacological properties of the monoterpenes p-cymene, including antioxidant, anti-inflammatory, antiparasitic, antidiabetic, antiviral, antitumor, antibacterial, and antifungal activities. The p-cymene has also been reported to act as an analgesic, antinociceptive, immunomodulatory, vasorelaxant and neuroprotective agent. Its anticancer effects are related to some mechanisms such as the inhibition of apoptosis and cell cycle arrest. In this review, we critically highlighted the in vitro and in vivo pharmacological properties of the p-cymene molecule, providing insight into its mechanisms of action and potential applications in drug discovery. In light of this finding, in-depth in vivo studies are strongly required to validate the safety and beneficial effects of the p-cymene molecule in human healthcare and industrial applications as a potential source of drug discovery.
对伞花烃，又称对伞花醇或对异丙基甲苯，是一种烷基取代的芳香族化合物，天然存在于各种芳香植物的精油（EOs）中，包括蒿属、伯乐树属、牛至属和百里香属。它与萜烯家族有关，特别是单环单萜烯。对伞花烃也存在于一些基于食物的植物中，如胡萝卜、橙汁、葡萄柚、橘子、覆盆子和几种香料。许多研究已经证明了单萜对伞花烃的药理学特性，包括抗氧化、抗炎、抗寄生虫、抗糖尿病、抗病毒、抗肿瘤、抗菌和抗真菌活性。对伞花烃还被报道具有镇痛、抗伤害感受、免疫调节、血管舒张和神经保护作用。其抗癌作用与一些机制有关，如抑制细胞凋亡和细胞周期阻滞。在这篇综述中，我们批判性地强调了对伞花烃分子的体外和体内药理学特性，深入了解其作用机制及其在药物发现中的潜在应用。鉴于这一发现，强烈需要进行深入的体内研究，以验证对伞花烃分子在人类保健和工业应用中的安全性和有益效果，作为药物发现的潜在来源。
