Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran university of medical science, Tehran, Iran.
Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Pharmacol Res. 2021 Jul;169:105665. doi: 10.1016/j.phrs.2021.105665. Epub 2021 May 11.
Previous studies have reported that vitamin C supplementation may decrease lipid profile in patients with type 2 diabetes mellitus (T2DM). This systematic review and meta-analysis evaluated the influence of vitamin C supplementation on lipid profile in patients with T2DM. Studies examining the effects of vitamin C supplementation on lipid profile in patients with T2DM, published up to November 2020, were identified through PubMed, SCOPUS, and Embase databases. 15 studies, including 872 participants, were included and analyzed using a random-effects model to calculate weighted mean differences (WMDs) with 95% confidence intervals (CI). Findings from 15 studies indicated that vitamin C supplementation significantly decreased Triglyceride (TG) (WMD: -16.48 mg/dl, 95% CI (-31.89, -1.08), P < 0.001) and total cholesterol (TC) (WMD: -13.00 mg/dl, 95% CI (-23.10, -2.91), P < 0.001) in patients with T2DM. However, vitamin C supplementation failed to improve LDL and HDL. The meta-regression analysis suggested that lipid profile improvement was affected by duration of vitamin C treatment. Dose-response analysis showed that vitamin C supplementation changed LDL significantly based on vitamin C dose. According to our findings, vitamin C supplementation significantly improved lipid profile via decreases in TG and TC. However, vitamin C failed to affect LDL and HDL in diabetic populations. It appears that vitamin C supplementation is more beneficial to lipid profile in long-term vs. short term interventions.
先前的研究报告称，维生素 C 补充剂可能会降低 2 型糖尿病（T2DM）患者的血脂谱。本系统评价和荟萃分析评估了维生素 C 补充剂对 T2DM 患者血脂谱的影响。通过 PubMed、SCOPUS 和 Embase 数据库，检索截至 2020 年 11 月发表的关于维生素 C 补充剂对 T2DM 患者血脂谱影响的研究。纳入 15 项研究，共 872 名参与者，采用随机效应模型计算加权均数差（WMD）及其 95%置信区间（CI）。15 项研究的结果表明，维生素 C 补充剂可显著降低 T2DM 患者的甘油三酯（TG）（WMD：-16.48mg/dl，95%CI（-31.89，-1.08），P<0.001）和总胆固醇（TC）（WMD：-13.00mg/dl，95%CI（-23.10，-2.91），P<0.001）。然而，维生素 C 补充剂未能改善 LDL 和 HDL。荟萃回归分析表明，血脂谱的改善受维生素 C 治疗时间的影响。剂量反应分析显示，根据维生素 C 剂量，维生素 C 补充剂显著改变了 LDL。根据我们的研究结果，维生素 C 补充剂通过降低 TG 和 TC 显著改善了血脂谱。然而，维生素 C 对糖尿病患者的 LDL 和 HDL 没有影响。维生素 C 补充剂在长期干预中比短期干预更有利于血脂谱。
