Department of Nephrology, Zhuji People's Hospital, Zhuji, Zhejiang 311800, China.
Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China.
J Healthc Eng. 2021 Apr 20;2021:5591124. doi: 10.1155/2021/5591124. eCollection 2021.
Peritoneal dialysis (PD), as one of the main renal replacement modalities for end-stage renal disease, gets the advantages of better protection of residual renal function and better quality of survival. However, ultrafiltration failure after peritoneal injury is an important reason for patients to withdraw from PD treatment. Peritonitis is a major complication of peritoneal dialysis, which results in an accelerated process of peritoneal injury due to direct damage from acute inflammation and local release of cytokine TGF-. In this paper, the application of ultrasound to examine the peritoneum revealed a positive correlation between peritoneal thickness and the development of peritonitis. The results of this study also further confirmed the effect of peritonitis on peritoneal thickening. A multifactorial regression analysis also revealed that peritonitis and its severity were independent risk factors for peritoneal thickening and omental structural abnormalities. This paper reported a correlation between mural peritoneal thickness and peritoneal transit function. In this study, patients with high peritoneal transit and high mean transit were found to be more prone to omental structural abnormalities than patients with low mean and low transit and a higher proportion of patients with mural peritoneal thickening, but this did not reach statistical significance, which may be related to the still small number of cases.
腹膜透析（PD）作为终末期肾病的主要肾脏替代方式之一，具有更好地保护残余肾功能和提高生存质量的优势。然而，腹膜损伤后的超滤衰竭是患者退出 PD 治疗的一个重要原因。腹膜炎是腹膜透析的主要并发症之一，由于急性炎症的直接损伤和细胞因子 TGF-的局部释放，导致腹膜损伤加速。本文应用超声检查腹膜，发现腹膜厚度与腹膜炎的发生呈正相关。研究结果也进一步证实了腹膜炎对腹膜增厚的影响。多因素回归分析还表明，腹膜炎及其严重程度是腹膜增厚和网膜结构异常的独立危险因素。本文报道了壁层腹膜厚度与腹膜转运功能之间的相关性。在这项研究中，发现腹膜转运功能高和平均转运时间长的患者比平均转运时间和转运时间短的患者更容易出现网膜结构异常，且壁层腹膜增厚的患者比例更高，但这并未达到统计学意义，这可能与病例数仍然较少有关。
