Liu Yong-Tai, Lai Jin-Zhi, Zhai Fei-Fei, Han Fei, Zhou Li-Xin, Ni Jun, Yao Ming, Tian Zhuang, Zhu Yan-Lin, Chen Wei, Bai Hua, Wang Hui, Zhang Ding-Ding, Cui Li-Ying, Jin Zheng-Yu, Zhu Yi-Cheng, Zhang Shu-Yang
Department of Cardiology, Peking Union Medical College, Chinese Academy of Medical Sciences, Peking Union Medical College Hospital, Beijing, China.
Department of Neurology, Peking Union Medical College, Chinese Academy of Medical Sciences, Peking Union Medical College Hospital, Beijing, China.
Ann Transl Med. 2021 Apr;9(8):640. doi: 10.21037/atm-20-6845.
Considerable evidence has been presented that heart and health-related quality of life are directly linked in patients with various diseases. This exploratory study investigated whether cardiac structure and function were associated with health-related quality of life in the general population.
This cross-sectional study was performed in five villages of Shunyi, a suburban district of Beijing, from June 2013 to April 2016. All inhabitants aged 35 years or older living in five villages of Shunyi were invited to participate. Exclusion criteria were individuals who declined participation, who had incomplete Health-related quality of life (HRQoL) data, and who had suboptimal echocardiograms. HRQoL was evaluated by the Mandarin version of SF-36. The association between the echocardiography-derived cardiac structure and function and each domain of SF-36 was analyzed by the multivariate linear regression analysis after adjusted for conventional risk factors affecting HRQoL.
The baseline data of 990 individuals were analyzed. The median age of the participants was 57 (50-63) years, and 367 (37.1%) were male, the average physical and mental component summary scores were 89.3 (79.8-94.3) and 90 (83.5-95) respectively. Tricuspid annular plane systolic excursion, an echocardiography-derived right ventricular parameter, was associated with all the subscales and summarized scores of SF-36 (all P<0.05). The independent association between tricuspid annular plane systolic excursion and physical/mental component summary scores remained after adjusting for age, gender, body mass index, education level, annual personal income, smoking and drinking status, and comorbidities (β=0.65, 95% confidence interval 0.30-1.01, P<0.01 and β=0.49, 95% confidence interval 0.23-0.76, P<0.01 for physical and mental component summary scores respectively). Compared with the participants with tricuspid annular plane systolic excursion ≥21 mm, the participants with tricuspid annular plane systolic excursion <21 mm had lower adjusted scores of physical and mental component summary scores (81.8 . 84.5, P=0.015, and 85.5 . 88.1, P<0.01 for physical and mental component summary scores respectively).
In this population-based study, right ventricular systolic function assessed by tricuspid annular plane systolic excursion was independently associated with health-related quality of life assessed by SF-36.
已有大量证据表明，患有各种疾病的患者的心脏与健康相关生活质量直接相关。这项探索性研究调查了心脏结构和功能是否与普通人群的健康相关生活质量有关。
这项横断面研究于2013年6月至2016年4月在北京郊区顺义的五个村庄进行。邀请了居住在顺义五个村庄的所有35岁及以上居民参与。排除标准为拒绝参与、健康相关生活质量（HRQoL）数据不完整以及超声心动图检查结果欠佳的个体。HRQoL通过中文版SF-36进行评估。在调整影响HRQoL的传统危险因素后，通过多变量线性回归分析超声心动图得出的心脏结构和功能与SF-36各领域之间的关联。
分析了990名个体的基线数据。参与者的中位年龄为57（50 - 63）岁，男性367名（37.1%），身体和心理成分综合得分平均分别为89.3（79.8 - 94.3）和90（83.5 - 95）。三尖瓣环平面收缩期位移，一项由超声心动图得出的右心室参数，与SF-36的所有子量表和综合得分相关（所有P<0.05）。在调整年龄、性别、体重指数、教育水平、个人年收入、吸烟和饮酒状况以及合并症后，三尖瓣环平面收缩期位移与身体/心理成分综合得分之间的独立关联仍然存在（身体和心理成分综合得分的β分别为0.65，95%置信区间0.30 - 1.01，P<0.01和β为0.49，95%置信区间0.23 - 0.76，P<0.01）。与三尖瓣环平面收缩期位移≥21 mm的参与者相比，三尖瓣环平面收缩期位移<21 mm的参与者身体和心理成分综合得分的调整后得分较低（身体成分综合得分分别为81.8对84.5，P = 0.015，心理成分综合得分分别为85.5对88.1，P<0.01）。
在这项基于人群的研究中，通过三尖瓣环平面收缩期位移评估的右心室收缩功能与通过SF-36评估的健康相关生活质量独立相关。
