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微小RNA-542-3p通过下调KDM1A和ZNF346抑制神经母细胞瘤细胞的增殖和侵袭。

MiR-542-3p Suppresses Neuroblastoma Cell Proliferation and Invasion by Downregulation of KDM1A and ZNF346.

作者信息

Wei Qiang, Guo Zhao, Chen Dong, Jia Xinjian

机构信息

Department II of General Surgery, Xi'an Children's Hospital, Xi'an, Shaanxi, China.

出版信息

Open Life Sci. 2020 Apr 10;15:173-184. doi: 10.1515/biol-2020-0018. eCollection 2020.

DOI:10.1515/biol-2020-0018
PMID:33987474
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8114778/
Abstract

Neuroblastoma is one of the most common malignancies in infants and children. MicroRNAs (miRNAs) have been reported as significant regulators that play important roles in neuroblastoma development. This research aimed to analyze the functional mechanism of miR-542-3p in neuroblastoma. Here, we found that miR-542-3p was downregulated and KDM1A as well as ZNF346 were upregulated in neuroblastoma tissues and cells. Both overexpression of miR-542-3p and the knockdown of KDM1A suppressed cell proliferation and invasion in neuroblastomas. Moreover, miR-542-3p reduced the levels of KDM1A and ZNF346 through interaction. Both KDM1A overexpression and ZNF346 upregulation weakened the effect of miR-542-3p on neuroblastoma cells. Besides, miR-542-3p negatively regulated tumor growth . Our results suggested that miR-542-3p suppressed cell proliferation and invasion by targeting KDM1A and ZNF346 in neuroblastomas, providing a theoretical basis for the treatment of neuroblastoma.

摘要

神经母细胞瘤是婴幼儿最常见的恶性肿瘤之一。微小RNA（miRNA）已被报道为在神经母细胞瘤发展中起重要作用的重要调节因子。本研究旨在分析miR-542-3p在神经母细胞瘤中的功能机制。在此，我们发现miR-542-3p在神经母细胞瘤组织和细胞中表达下调，而KDM1A和ZNF346表达上调。miR-542-3p的过表达和KDM1A的敲低均抑制了神经母细胞瘤细胞的增殖和侵袭。此外，miR-542-3p通过相互作用降低了KDM1A和ZNF346的水平。KDM1A的过表达和ZNF346的上调均削弱了miR-542-3p对神经母细胞瘤细胞的作用。此外，miR-542-3p对肿瘤生长具有负调控作用。我们的结果表明，miR-542-3p通过靶向KDM1A和ZNF346抑制神经母细胞瘤细胞的增殖和侵袭，为神经母细胞瘤的治疗提供了理论依据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c810/8114778/38982544391f/biol-15-173-g008.jpg
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