一种用于苯乙烯环氧化的海藻酸钠约束过氧化物酶-CLEA。
An alginate-confined peroxygenase-CLEA for styrene epoxidation.
机构信息
Department of Biotechnology, Delft University of Technology, van der Maasweg 9, 2629 HZ, Delft, The Netherlands.
Department of Biosystems Science and Engineering, ETH Zürich, Mattenstrasse 26, Basel 4058, Switzerland.
出版信息
Chem Commun (Camb). 2021 Jun 10;57(47):5766-5769. doi: 10.1039/d1cc01868j.
Oxyfunctionalisation reactions in neat substrate still pose a challenge for biocatalysis. Here, we report an alginate-confined peroxygenase-CLEA to catalyse the enantioselective epoxidation of cis-β-methylstyrene in a solvent-free reaction system achieving turnover numbers of 96 000 for the biocatalyst and epoxide concentrations of 48 mM.
在纯底物中进行氧化官能化反应仍然是生物催化的一个挑战。在这里，我们报告了一种用藻酸盐包封的过氧化物酶-CLEA 来催化顺式-β-甲基苯乙烯的对映选择性环氧化反应，在无溶剂反应体系中实现了 96000 的生物催化剂转化数和 48mM 的环氧化物浓度。
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