Beijing Advanced Innovation Center for Soft Matter Science and Engineering, State Key Laboratory of Organic-Inorganic Composites, Beijing Laboratory of Biomedical Materials, Bionanomaterials & Translational Engineering Laboratory, Beijing Key Laboratory of Bioprocess, Beijing University of Chemical Technology, Beijing, 100029, P. R. China.
Beijing National Laboratory of Molecular Sciences, Key Laboratory of Green Printing, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
Adv Mater. 2021 Jun;33(25):e2007073. doi: 10.1002/adma.202007073. Epub 2021 May 13.
Sonodynamic therapy (SDT) is a non-invasive and highly penetrating treatment strategy under ultrasound irradiation. However, uncertainty in the mechanism of SDT has seriously hindered its future clinical application. Here, the mechanism of SDT enhanced by the wettability of nanoparticles is investigated. Nanoparticles can adsorb and stabilize nanobubbles in liquid, thus enhancing SDT efficiency. The stability of the nanobubbles is positively correlated with the desorption energy of the nanoparticles, which is determined by the wettability of the nanoparticles. This conclusion is verified for mesoporous silica and polystyrene nanoparticles and it is found that nanoparticles with a water contact angle of about 90° possess the largest desorption energy. To further apply this conclusion, thrombus models are constructed on rats and the experimental results demonstrate that nanoparticles with the largest desorption energy have the highest thrombolytic efficiency. It is believed that these findings will help to better understand the SDT mechanism and guide new strategies for rational design of nanoparticles adopted in SDT.
声动力学疗法（SDT）是一种在超声辐射下的非侵入性、高穿透性的治疗策略。然而，SDT 机制的不确定性严重阻碍了其未来的临床应用。在这里，研究了纳米粒子润湿性增强的 SDT 机制。纳米粒子可以在液体中吸附和稳定纳米气泡，从而提高 SDT 的效率。纳米气泡的稳定性与纳米粒子的解吸能呈正相关，而解吸能由纳米粒子的润湿性决定。这一结论通过介孔硅和聚苯乙烯纳米粒子得到了验证，并且发现具有约 90°水接触角的纳米粒子具有最大的解吸能。为了进一步应用这一结论，在大鼠上构建了血栓模型，实验结果表明具有最大解吸能的纳米粒子具有最高的溶栓效率。相信这些发现将有助于更好地理解 SDT 机制，并指导用于 SDT 的纳米粒子的合理设计的新策略。
