Zhang Haoyuan, Pan Xueting, Wu Qingyuan, Guo Juan, Wang Chaohui, Liu Huiyu
Beijing Advanced Innovation Center for Soft Matter Science and Engineering, State Key Laboratory of Organic-Inorganic Composites, Beijing Laboratory of Biomedical Materials, Bionanomaterials & Translational Engineering Laboratory, Beijing Key Laboratory of Bioprocess Beijing University of Chemical Technology Beijing P. R. China.
Exploration (Beijing). 2021 Sep 30;1(2):20210010. doi: 10.1002/EXP.20210010. eCollection 2021 Oct.
Sonodynamic therapy (SDT) has attracted widespread attention due to its non-invasiveness and deep tissue penetration. However, the development of efficient sonodynamic nanoplatforms to improve the therapeutic efficiency is still one of the main challenges of current research. In this work, a new type of sonosensitizer prepared by a simple method, manganese carbonate nanoparticles (MnCO NPs), is used for enhanced SDT. MnCO NPs could generate large amounts of O and •OH under ultrasound irradiation. At the same time, CO and Mn ions could be released in a weak acid environment due to the excellent degradability of MnCO NPs. The CO bubbles caused cell necrosis by ultrasonic cavitation and used for ultrasound imaging. And Mn ions activated the mitochondrial cell apoptosis pathway. In vivo experiments proved that this sonosensitizer with mitochondrial regulatory capacity showed high tumor inhibition rates for enhanced sonodynamic tumor therapy.
声动力疗法（SDT）因其非侵入性和深层组织穿透性而受到广泛关注。然而，开发高效的声动力纳米平台以提高治疗效果仍然是当前研究的主要挑战之一。在这项工作中，一种通过简单方法制备的新型声敏剂——碳酸锰纳米颗粒（MnCO NPs）被用于增强声动力疗法。MnCO NPs在超声照射下可产生大量的O和•OH。同时，由于MnCO NPs具有优异的可降解性，CO和Mn离子可在弱酸环境中释放。CO气泡通过超声空化作用导致细胞坏死，并用于超声成像。而Mn离子激活线粒体细胞凋亡途径。体内实验证明，这种具有线粒体调节能力的声敏剂在增强声动力肿瘤治疗中显示出高肿瘤抑制率。
