Farhadi Mohammad, Razmara Ehsan, Balali Maryam, Hajabbas Farshchi Yeganeh, Falah Masoumeh
ENT and Head and Neck Research Center and Department, The Five Senses Health Institute, Hazrat Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
Australian Regenerative Medicine Institute, Monash University, Clayton, VIC, Australia.
J Cell Mol Med. 2021 May 13;25(13):5869-83. doi: 10.1111/jcmm.16610.
Different cellular mechanisms contribute to the hearing sense, so it is obvious that any disruption in such processes leads to hearing impairment that greatly influences the global economy and quality of life of the patients and their relatives. In the past two decades, transmembrane inner ear (TMIE) protein has received a great deal of research interest because its impairments cause hereditary deafness in humans. This evolutionarily conserved membrane protein contributes to a fundamental complex that plays role in the maintenance and function of the sensory hair cells. Although the critical roles of the TMIE in mechanoelectrical transduction or hearing procedures have been discussed, there are little to no review papers summarizing the roles of the TMIE in the auditory system. In order to fill this gap, herein, we discuss the important roles of this protein in the auditory system including its role in mechanotransduction, olivocochlear synapse, morphology and different signalling pathways; we also review the genotype-phenotype correlation that can per se show the possible roles of this protein in the auditory system.
不同的细胞机制对听觉起着作用，因此很明显，这些过程中的任何干扰都会导致听力障碍，这对全球经济以及患者及其亲属的生活质量产生重大影响。在过去二十年中，跨膜内耳（TMIE）蛋白受到了大量研究关注，因为其功能受损会导致人类遗传性耳聋。这种在进化上保守的膜蛋白是一个基本复合体的组成部分，该复合体在感觉毛细胞的维持和功能中发挥作用。尽管已经讨论了TMIE在机械电转导或听力过程中的关键作用，但几乎没有综述文章总结TMIE在听觉系统中的作用。为了填补这一空白，在此我们讨论该蛋白在听觉系统中的重要作用，包括其在机械转导、橄榄耳蜗突触、形态学和不同信号通路中的作用；我们还综述了基因型 - 表型相关性，其本身可以显示该蛋白在听觉系统中的可能作用。
