T 细胞受体(TCR)样抗体在宫颈癌免疫治疗中的潜在应用。

The potential applications of T cell receptor (TCR)-like antibody in cervical cancer immunotherapy.

机构信息

Institute for Research in Molecular Medicine, Universiti Sains Malaysia, George Town, Malaysia.

出版信息

Hum Vaccin Immunother. 2021 Sep 2;17(9):2981-2994. doi: 10.1080/21645515.2021.1913960. Epub 2021 May 14.

Abstract

Cervical cancer is ranked as the fourth most common cancer in women worldwide. Monoclonal antibody has created a new dimension in the immunotherapy of many diseases, including cervical cancer. The antibody's ability to target various aspects of cervical cancer (oncoviruses, oncoproteins, and signaling pathways) delivers a promising future for efficient immunotherapy. Besides, technologies such as hybridoma and phage display provide a fundamental platform for monoclonal antibody generation and create the opportunity to generate novel antibody classes including, T cell receptor (TCR)-like antibody. In this review, the current immunotherapy strategies for cervical cancer are presented. We have also proposed a novel concept of T cell receptor (TCR)-like antibody and its potential applications for enhancing cervical cancer therapeutics. Finally, the possible challenges in TCR-like antibody application for cervical cancer therapeutics have been addressed, and strategies to overcome the challenges have been highlighted to maximize the therapeutic benefits.

摘要

宫颈癌在全球范围内是女性中第四大常见癌症。单克隆抗体在许多疾病的免疫治疗中开辟了一个新的维度,包括宫颈癌。抗体靶向宫颈癌的各个方面(致癌病毒、癌蛋白和信号通路)的能力为有效的免疫治疗带来了广阔的前景。此外,杂交瘤和噬菌体展示等技术为单克隆抗体的产生提供了一个基本的平台,并创造了产生新型抗体类别的机会,包括 T 细胞受体 (TCR)-样抗体。在这篇综述中,介绍了目前用于宫颈癌的免疫治疗策略。我们还提出了一种新型的 T 细胞受体 (TCR)-样抗体的概念及其在增强宫颈癌治疗中的潜在应用。最后,讨论了 TCR 样抗体在宫颈癌治疗中的应用可能面临的挑战,并提出了克服这些挑战的策略,以最大限度地提高治疗效果。

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