Department of Pharmaceutical Technology, School of Pharmacy, International Medical University (IMU), Kuala Lumpur, Malaysia.
Neuropsychopharmacology Division, Department of Pharmacy, Birla Institute of Technology and Science, Pilani, India.
J Pharm Sci. 2021 Sep;110(9):3111-3117. doi: 10.1016/j.xphs.2021.05.001. Epub 2021 May 11.
Human serum albumin or simply called albumin is a flexible protein employed as a carrier in the fabrication of albumin-based nanocarriers (ANCs) for the administration of cancer therapeutics. Albumin can contribute enhanced tumour specificity, reduced drug induced cytotoxicity and retain concentration of the therapeutically active agent such as drug, peptide, protein, and gene for a prolonged time duration. Nevertheless, apart from cancer management, ANCs are also employed in the diagnosis, imaging, and multimodal cancer therapy. This article figures out salient characteristics, design as well as categories of ANCs in the context of their application in cancer management. In addition, this review article discusses the fabrication methods of ANCs, use of ANCs in gene, cancer, and multimodal therapy along with cancer diagnosis and imaging. Lastly, this review also briefly discusses about (ANCs) formulations, commercial products, and those under clinical testing.
人血清白蛋白或简称白蛋白，是一种灵活的蛋白质，被用作基于白蛋白的纳米载体（ANCs）的载体，用于癌症治疗药物的给药。白蛋白可以提高肿瘤特异性，降低药物诱导的细胞毒性，并在延长的时间内保持治疗活性剂（如药物、肽、蛋白质和基因）的浓度。然而，除了癌症管理外，ANCs 还用于诊断、成像和多模式癌症治疗。本文阐述了 ANCs 在癌症管理中的应用背景下的突出特点、设计和分类。此外，本文综述还讨论了 ANCs 的制备方法，以及 ANCs 在基因、癌症和多模式治疗以及癌症诊断和成像中的应用。最后，本文还简要讨论了（ANCs）制剂、商业产品和临床测试中的产品。
