Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka, 814-0180, Japan.
Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka, 814-0180, Japan.
Biochem Biophys Res Commun. 2021 Jun 30;560:146-151. doi: 10.1016/j.bbrc.2021.04.132. Epub 2021 May 12.
Adenosine triphosphate (ATP) is the most vital energy source produced mainly in the mitochondria. Age-related mitochondrial dysfunction is associated with brain diseases. Nicotinamide adenine dinucleotide (NAD) is an essential cofactor for energy production in mitochondria. Here, we examined how the novel NAD-assisting substance, 10-ethyl-3-methylpyrimido[4,5-b]quinoline-2,4(3H,10H)-dione (TND1128), modulates the morphological growth of cultured mouse hippocampal neurons. The morphological growth effect of TND1128 was also compared with that of β-nicotinamide mononucleotide (β-NMN). TND1128 induced the branching of axons and dendrites, and increased the number of excitatory synapses. This study provides new insight into TND1128 as a mitochondria-stimulating drug for improving brain function.
三磷酸腺苷（ATP）是主要在线粒体中产生的最关键的能量来源。与年龄相关的线粒体功能障碍与脑部疾病有关。烟酰胺腺嘌呤二核苷酸（NAD）是线粒体中能量产生的必需辅助因子。在这里，我们研究了新型 NAD 辅助物质 10-乙基-3-甲基嘧啶并[4,5-b]喹啉-2,4(3H,10H)-二酮（TND1128）如何调节培养的小鼠海马神经元的形态生长。还比较了 TND1128 与β-烟酰胺单核苷酸（β-NMN）的形态生长作用。TND1128 诱导轴突和树突的分支，并增加兴奋性突触的数量。这项研究为 TND1128 作为一种改善大脑功能的线粒体刺激药物提供了新的见解。
