阿尔茨海默病中多巴胺-β-羟化酶活性降低。
Reduced dopamine-beta-hydroxylase activity in Alzheimer's disease.
作者信息
Cross A J, Crow T J, Perry E K, Perry R H, Blessed G, Tomlinson B E
出版信息
Br Med J (Clin Res Ed). 1981 Jan 10;282(6258):93-4. doi: 10.1136/bmj.282.6258.93.
Abstract
The activity of the noradrenergic marker enzyme dopamine-beta-hydroxylase was measured in brains removed postmortem from control patients and patients with Alzheimer's disease. Enzyme activity was decreased in the frontal and temporal cortices and hippocampus in patients with Alzheimer's disease, but was within the normal range in patients with depression, multiinfarct dementia, and terminal coma.The decrease in enzyme activity in Alzheimer's disease may reflect an abnormality of cortical noradrenergic fibres in some patients with the disease.
摘要
对对照组患者以及阿尔茨海默病患者死后取出的大脑进行去甲肾上腺素能标记酶多巴胺-β-羟化酶活性的检测。阿尔茨海默病患者额叶、颞叶皮质及海马体中的酶活性降低，但抑郁症患者、多发梗死性痴呆患者及终末期昏迷患者的酶活性处于正常范围内。阿尔茨海默病患者酶活性的降低可能反映了部分该病患者皮质去甲肾上腺素能纤维存在异常。
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本文引用的文献
1
A sensitive enzymatic assay for dopamine- -hydroxylase.一种用于多巴胺-β-羟化酶的灵敏酶促测定法。
J Pharmacol Exp Ther. 1971 Sep;178(3):425-31.
2
Observations on the brains of demented old people.对老年痴呆症患者大脑的观察。
J Neurol Sci. 1970 Sep;11(3):205-42. doi: 10.1016/0022-510x(70)90063-8.
3
Brain aluminum distribution in Alzheimer's disease and experimental neurofibrillary degeneration.阿尔茨海默病及实验性神经原纤维变性中的脑铝分布
Science. 1973 May 4;180(4085):511-3. doi: 10.1126/science.180.4085.511.
4
Impaired learning and decreased cortical norepinephrine after bilateral locus coeruleus lesions.双侧蓝斑核损伤后学习能力受损及皮质去甲肾上腺素减少。
Science. 1973 Aug 17;181(4100):682-4. doi: 10.1126/science.181.4100.682.
5
Some observations on the interaction of dopamine-beta-hydroxylase and its natural inhibitors in the rat brain.关于大鼠脑中多巴胺-β-羟化酶及其天然抑制剂相互作用的一些观察
Can J Biochem. 1976 Nov;54(11):988-91. doi: 10.1139/o76-142.
6
7
Selective vulnerability of neurones in organic dementia.器质性痴呆中神经元的选择性易损性。
Nature. 1977 Apr 7;266(5602):558-9. doi: 10.1038/266558a0.
8
Aluminum levels in brain in Alzheimer's disease.阿尔茨海默病患者大脑中的铝含量。
Biol Psychiatry. 1978 Dec;13(6):709-18.
9
Memory impairment in Korsakoff's psychosis: a correlation with brain noradrenergic activity.科萨科夫精神病中的记忆障碍：与脑去甲肾上腺素能活性的相关性。
Science. 1978 Nov 24;202(4370):905-7. doi: 10.1126/science.715450.
10
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