Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Clinical Research Development Unit, Shohada-e Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Dermatol Ther. 2021 Jul;34(4):e14979. doi: 10.1111/dth.14979. Epub 2021 May 27.
The aim of this study was to evaluate metabolic syndrome prevalence in patients with Alopecia Areata compared to controls. Sixty eligible patients with Alopecia Areata and 60 healthy subjects frequency matched for age and sex attending to our referral dermatology clinics from 2015 to 2017 were enrolled. Prevalence of metabolic syndrome and its components were compared between the two groups. Metabolic syndrome was only seen in seven patients (11.67%) and four controls (6.67%) without a significant difference (P = .34). The clinical presentations of AA included patch type (38.33%), ophiasis (6.67%), alopecia totalis (16.67%), and alopecia universalis (38.33%). Presence of metabolic syndrome was significantly associated with abdominal circumference (OR: 1.10, 95% CI for OR: 1.02to 1.19). Although there was no significant association between Alopecia Areata and metabolic syndrome, some components of metabolic syndrome were more prevalent in these patients. It may be concluded Alopecia Areata patients are at a higher risk of developing metabolic syndrome in the future. Further studies with larger sample sizes are needed.
本研究旨在评估斑秃患者与对照组相比代谢综合征的患病率。2015 年至 2017 年期间，我们从就诊的皮肤科患者中选择了 60 名符合条件的斑秃患者和 60 名年龄和性别相匹配的健康受试者。比较了两组之间代谢综合征及其各组分的患病率。仅 7 名患者（11.67%）和 4 名对照者（6.67%）存在代谢综合征，但差异无统计学意义（P=.34）。AA 的临床表现包括斑片状（38.33%）、蛇形（6.67%）、全秃（16.67%）和普秃（38.33%）。代谢综合征的存在与腰围显著相关（OR：1.10，95%CI for OR：1.02 to 1.19）。尽管斑秃与代谢综合征之间无显著关联，但这些患者的代谢综合征某些组分更为普遍。可以得出结论，斑秃患者未来发生代谢综合征的风险更高。需要进一步开展更大样本量的研究。
