Department of Psychological Sciences, Birkbeck, University of London, London, UK.
Birkbeck Centre for Building Resilience in Breast Cancer (BRiC), London, UK.
Psychooncology. 2021 Sep;30(9):1563-1571. doi: 10.1002/pon.5732. Epub 2021 May 24.
Previous literature has established a relationship between cognitive function and symptoms of anxiety, depression, and post-traumatic stress in primary breast cancer, but not in metastatic breast cancer (MBC). The current study examined the relationship between cognitive function and symptoms of anxiety, depression, and post-traumatic stress as well as the moderating effects of age, time since MBC diagnosis, and social support.
Subjective and objective measures of cognitive function as well as self-reports of emotional vulnerability were completed by 59 women diagnosed with MBC who were recruited through social media and support groups.
Emotional vulnerability scores were associated with perceived measures of cognitive function. Additionally, low levels of perceived cognitive function were met with increased levels of depression with social support moderating this relationship buffering against depression. Age was found to moderate the relationship between cognitive function and post-traumatic stress with younger women at a greater risk of vulnerability. Out of all the emotional vulnerability measures, only anxiety negatively correlated with objective task performance.
This study established a relationship between cognitive function and emotional vulnerability in MBC patients. It emphasised how vulnerable younger MBC women are to post-traumatic stress, and the importance of the combined effects of cognitive function and social support in buffering against depression. Our results have important implications for developing new interventions and treatment plans that consider the roles of these factors in ensuring a better quality of life in MBC.
既往文献已证实原发性乳腺癌患者的认知功能与焦虑、抑郁和创伤后应激症状之间存在关联，但转移性乳腺癌（MBC）患者则不然。本研究旨在探讨认知功能与焦虑、抑郁和创伤后应激症状之间的关系，以及年龄、MBC 诊断后时间和社会支持的调节作用。
通过社交媒体和支持小组招募了 59 名被诊断为 MBC 的女性，完成了认知功能的主观和客观测量以及情绪脆弱性的自我报告。
情绪脆弱性评分与感知认知功能测量结果相关。此外，感知认知功能水平较低与抑郁水平升高相关，而社会支持则调节了这种关系，缓冲了抑郁的发生。年龄被发现调节了认知功能与创伤后应激之间的关系，年轻女性更容易出现脆弱性。在所有情绪脆弱性测量指标中，只有焦虑与客观任务表现呈负相关。
本研究在 MBC 患者中确立了认知功能与情绪脆弱性之间的关系。研究强调了年轻的 MBC 女性易受创伤后应激影响，以及认知功能和社会支持的综合作用在缓冲抑郁方面的重要性。我们的研究结果对制定新的干预和治疗计划具有重要意义，这些计划需要考虑这些因素在确保 MBC 患者生活质量方面的作用。
