Melbourne Medical School, University of Melbourne, Parkville, Victoria.
The Florey Institute of Neuroscience and Mental Health, Melbourne Brain Centre, Austin Campus, Heidelberg, Victoria.
Arch Phys Med Rehabil. 2021 Aug;102(8):1633-1644. doi: 10.1016/j.apmr.2021.04.010. Epub 2021 May 14.
To provide a novel overview of the literature and to summarize the evidence for the effects of aerobic exercise (AE) on serum biomarkers neuroplasticity and brain repair in survivors of stroke.
We conducted a systematic review and searched MEDLINE, Embase, and Cochrane CENTRAL using terms related to AE, neuroplasticity, brain repair, and stroke.
Titles, abstracts, and selected full texts were screened by 2 independent reviewers against the following inclusion criteria: including adult survivors of stroke, completing an AE intervention working within the AE capacity, and measuring at least 1 blood biomarker outcome of interest.
Two independent reviewers extracted data and assessed risk of bias using Risk of Bias in Nonrandomized Studies-of Interventions and Cochrane's Risk of Bias 2 tools.
Nine studies (n=215 participants) were included, reporting on the following outcomes: brain-derived neurotrophic factor (BDNF), insulin-like growth factor 1 (IGF-1), vascular endothelial growth factor (VEGF), cortisol, interleukin 6, and myeloperoxidase. A single bout of high-intensity interval training significantly increased BDNF, IGF-1, and VEGF levels, and a 40-45-minute, 24-session, continuous 8-week AE training program significantly increased BDNF levels. No significant difference in response to any other AE intervention was found in other serum biomarkers.
AE can significantly increase BDNF, IGF-1, and VEGF across different AE protocols in survivors of stroke. However, more research is needed to determine the optimal exercise intensity and modalities, specifically in survivors of acute and subacute stroke, and how this may relate to functional outcomes.
提供文献综述的新视角，并总结有氧运动（AE）对脑卒中幸存者血清神经可塑性和脑修复生物标志物影响的证据。
我们系统地检索了 MEDLINE、Embase 和 Cochrane CENTRAL 数据库，使用与 AE、神经可塑性、脑修复和中风相关的术语。
两名独立审查员根据以下纳入标准筛选标题、摘要和选定的全文：纳入成年脑卒中幸存者、完成 AE 干预且在 AE 能力范围内、测量至少 1 个感兴趣的血液生物标志物结果。
两名独立审查员提取数据，并使用非随机干预研究中的偏倚风险评估工具和 Cochrane 偏倚风险 2 工具评估偏倚风险。
纳入了 9 项研究（n=215 名参与者），报告了以下结果：脑源性神经营养因子（BDNF）、胰岛素样生长因子 1（IGF-1）、血管内皮生长因子（VEGF）、皮质醇、白细胞介素 6 和髓过氧化物酶。单次高强度间歇训练显著增加了 BDNF、IGF-1 和 VEGF 水平，而 40-45 分钟、24 次、连续 8 周的 AE 训练计划显著增加了 BDNF 水平。在其他血清生物标志物中，没有发现任何其他 AE 干预的反应有显著差异。
AE 可以在不同的 AE 方案中显著增加脑卒中幸存者的 BDNF、IGF-1 和 VEGF。然而，需要更多的研究来确定最佳的运动强度和方式，特别是在急性和亚急性脑卒中幸存者中，以及这如何与功能结果相关。
