Hung Stanley Hughwa, Kramer Sharon, Werden Emilio, Campbell Bruce C V, Brodtmann Amy
The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, VIC, Australia.
Centre for Quality and Patient Safety Research, Alfred Health Partnership, Melbourne, VIC, Australia.
Front Neurol. 2022 Feb 15;13:804187. doi: 10.3389/fneur.2022.804187. eCollection 2022.
Favorable cerebral collateral circulation contributes to hindering penumbral tissue from progressing to infarction and is associated with positive clinical outcomes after stroke. Given its clinical importance, improving cerebral collateral circulation is considered a therapeutic target to reduce burden after stroke. We provide a hypothesis-generating discussion on the potential association between pre-stroke physical activity and cerebral collateral circulation in ischemic stroke. The recruitment of cerebral collaterals in acute ischemic stroke may depend on anatomical variations, capacity of collateral vessels to vasodilate, and individual risk factors. Physical activity is associated with improved cerebral endothelial and vascular function related to vasodilation and angiogenic adaptations, and risk reduction in individual risk factors. More research is needed to understand association between cerebral collateral circulation and physical activity. A presentation of different methodological considerations for measuring cerebral collateral circulation and pre-stroke physical activity in the context of acute ischemic stroke is included. Opportunities for future research into cerebral collateral circulation, physical activity, and stroke recovery is presented.
良好的脑侧支循环有助于阻止半暗带组织进展为梗死，并且与卒中后的良好临床结局相关。鉴于其临床重要性，改善脑侧支循环被视为减轻卒中后负担的治疗靶点。我们针对缺血性卒中患者卒中前身体活动与脑侧支循环之间的潜在关联进行了一次产生假设的讨论。急性缺血性卒中时脑侧支的募集可能取决于解剖变异、侧支血管的血管舒张能力以及个体危险因素。身体活动与改善的脑内皮和血管功能相关，这些功能与血管舒张和血管生成适应性有关，并且能降低个体危险因素。需要更多研究来了解脑侧支循环与身体活动之间的关联。本文还介绍了在急性缺血性卒中背景下测量脑侧支循环和卒中前身体活动的不同方法学考量。本文还提出了未来针对脑侧支循环、身体活动和卒中恢复进行研究的机会。
