阿替洛尔与氧烯洛尔在心绞痛或高血压合并慢性气道阻塞患者中的比较。
Comparison of atenolol and oxprenolol in patients with angina or hypertension and co-existent chronic airways obstruction.
作者信息
Perks W H, Chatterjee S S, Croxson R S, Cruickshank J M
出版信息
Br J Clin Pharmacol. 1978 Feb;5(2):101-6. doi: 10.1111/j.1365-2125.1978.tb01608.x.
Abstract
1 The effects of atenolol (50 mg and 100 mg) and oxprenolol (80 mg) on respiratory function were studied in ten patients with angina pectoris or hypertension complicated by chronic airways obstruction. 2 In patients with "fixed" airways obstruction, neither atenolol nor exprenolol significantly affected airways resistance. 3 In patients with "labile" airways obstruction, atenolol did not produce a significant increase in airways obstruction, whereas oxprenolol did. 4 Following isoprenaline challenge (1500 microgram by inhalation), atenolol permitted full bronchodilatation, whereas oxprenolol almost completely blocked the action of isoprenaline. 5 Partial agonist activity appears to be of less clinical importance than cardioselectivity.
摘要
- 对10例患有心绞痛或高血压并伴有慢性气道阻塞的患者，研究了阿替洛尔（50毫克和100毫克）和氧烯洛尔（80毫克）对呼吸功能的影响。2. 在患有“固定性”气道阻塞的患者中，阿替洛尔和氧烯洛尔均未显著影响气道阻力。3. 在患有“易变性”气道阻塞的患者中，阿替洛尔未使气道阻塞显著增加，而氧烯洛尔则会。4. 吸入异丙肾上腺素（1500微克）激发后，阿替洛尔可使支气管充分扩张，而氧烯洛尔几乎完全阻断了异丙肾上腺素的作用。5. 部分激动剂活性似乎不如心脏选择性具有临床重要性。
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本文引用的文献
1
Practolol in the treatment of tachyarrhythmias in patients with bronchial asthma.心得宁治疗支气管哮喘患者的快速心律失常
Am Heart J. 1972 Nov;84(5):710-2. doi: 10.1016/0002-8703(72)90189-5.
2
Beta-adrenergic blocking drugs.β-肾上腺素能阻断药
Br Med J. 1971 Jun 12;2(5762):652. doi: 10.1136/bmj.2.5762.652-b.
3
Metabolic studies on oxprenolol in animals and man by means of radio-tracer techniques and GLC-analysis.采用放射性示踪技术和气相色谱分析法对动物及人体中的氧烯洛尔进行代谢研究。
Postgrad Med J. 1970 Nov:Suppl:32-9.
4
Comparison of the effect of alprenolol and propranolol on specific airway conductance in asthmatic subjects.阿普洛尔与普萘洛尔对哮喘患者气道比传导率影响的比较。
Br Med J. 1970 May 30;2(5708):515-6. doi: 10.1136/bmj.2.5708.515.
5
The beta-blocking effect of practolol in asthmatics.心得宁对哮喘患者的β受体阻滞作用。
Lancet. 1970 Sep 26;2(7674):662. doi: 10.1016/s0140-6736(70)91429-7.
6
Effect of a new beta-adrenergic blocking agent, ICI 66o82, on exercise haemodynamics and airway resistance in angina pectoris.新型β-肾上腺素能阻滞剂ICI 66082对心绞痛患者运动血流动力学和气道阻力的影响。
Br Heart J. 1974 Dec;36(12):1194-1200. doi: 10.1136/hrt.36.12.1194.
7
Practolol treatment in asthmatics.心得宁在哮喘患者中的治疗应用。
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10
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