低氧血症的严重程度可能解释了吸入一氧化氮儿科试验中不确定的结果。 - Suppr

Severity of hypoxemia may explain indeterminate results in pediatric trials of inhaled nitric oxide.

作者信息

Yehya Nadir, Harhay Michael O

机构信息

Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia and University of Pennsylvania, 6040A Wood Building, CHOP, 3401 Civic Center Boulevard, Philadelphia, PA, 19104, USA.

Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA, USA.

出版信息

Intensive Care Med. 2021 Aug;47(8):913-915. doi: 10.1007/s00134-021-06434-x. Epub 2021 May 16.

DOI:10.1007/s00134-021-06434-x

PMID:33993339

Abstract

摘要

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Severity of hypoxemia may explain indeterminate results in pediatric trials of inhaled nitric oxide.低氧血症的严重程度可能解释了吸入一氧化氮儿科试验中不确定的结果。

Intensive Care Med. 2021 Aug;47(8):913-915. doi: 10.1007/s00134-021-06434-x. Epub 2021 May 16.

Inhaled nitric oxide does not reduce mortality in patients with acute respiratory distress syndrome regardless of severity: systematic review and meta-analysis.吸入一氧化氮并不能降低急性呼吸窘迫综合征患者的死亡率，无论疾病严重程度如何：系统评价和荟萃分析。

Crit Care Med. 2014 Feb;42(2):404-12. doi: 10.1097/CCM.0b013e3182a27909.

Inhaled Nitric Oxide for Clinical Management of COVID-19: A Systematic Review and Meta-Analysis.吸入一氧化氮治疗 COVID-19 的临床管理：系统评价和荟萃分析。

Int J Environ Res Public Health. 2022 Oct 6;19(19):12803. doi: 10.3390/ijerph191912803.

Inhaled nitric oxide for acute respiratory distress syndrome (ARDS) in children and adults.吸入一氧化氮用于儿童和成人急性呼吸窘迫综合征（ARDS）的治疗

Cochrane Database Syst Rev. 2016 Jun 27;2016(6):CD002787. doi: 10.1002/14651858.CD002787.pub3.

Inhaled nitric oxide for acute hypoxemic respiratory failure in children and adults.吸入一氧化氮治疗儿童和成人急性低氧性呼吸衰竭。

Cochrane Database Syst Rev. 2003(1):CD002787. doi: 10.1002/14651858.CD002787.

[Inhaled nitric oxide for rescue treatment of refractory hypoxemia in ARDS patients].吸入一氧化氮用于急性呼吸窘迫综合征患者难治性低氧血症的抢救治疗

Anasthesiol Intensivmed Notfallmed Schmerzther. 2008 Nov;43(11-12):778-83; quiz 784. doi: 10.1055/s-0028-1104618. Epub 2008 Nov 18.

Association of Response to Inhaled Nitric Oxide and Duration of Mechanical Ventilation in Pediatric Acute Respiratory Distress Syndrome.儿童急性呼吸窘迫综合征中对吸入一氧化氮的反应与机械通气时间的关系。

Pediatr Crit Care Med. 2017 Nov;18(11):1019-1026. doi: 10.1097/PCC.0000000000001305.

Dose response to inhaled nitric oxide in pediatric patients with pulmonary hypertension and acute respiratory distress syndrome.肺动脉高压和急性呼吸窘迫综合征患儿对吸入一氧化氮的剂量反应。

J Pediatr. 1997 Jul;131(1 Pt 1):63-9. doi: 10.1016/s0022-3476(97)70125-2.

Reversal of hypoxemia by inhaled nitric oxide in children with severe hepatopulmonary syndrome, type 1, during and after liver transplantation.肝移植期间及术后吸入一氧化氮对1型严重肝肺综合征患儿低氧血症的逆转作用。

Transplantation. 1998 Feb 15;65(3):437-9. doi: 10.1097/00007890-199802150-00026.

Inhaled nitric oxide therapy and risk of renal dysfunction: a systematic review and meta-analysis of randomized trials.吸入一氧化氮疗法与肾功能不全风险：一项随机试验的系统评价和荟萃分析

Crit Care. 2015 Apr 3;19(1):137. doi: 10.1186/s13054-015-0880-2.

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Stratifying Severity of Acute Respiratory Failure Severity in Cyanotic Congenital Heart Disease.对发绀型先天性心脏病急性呼吸衰竭严重程度进行分层。

Pediatr Cardiol. 2023 Aug;44(6):1271-1276. doi: 10.1007/s00246-023-03160-7. Epub 2023 Apr 15.

More questions than answers for the use of inhaled nitric oxide in COVID-19.关于 COVID-19 中吸入一氧化氮的应用，问题多于答案。

Nitric Oxide. 2022 Jul 1;124:39-48. doi: 10.1016/j.niox.2022.05.001. Epub 2022 May 6.

本文引用的文献

Predicting Mortality in Children With Pediatric Acute Respiratory Distress Syndrome: A Pediatric Acute Respiratory Distress Syndrome Incidence and Epidemiology Study.预测儿科急性呼吸窘迫综合征患儿的死亡率：儿科急性呼吸窘迫综合征发生率和流行病学研究。

Crit Care Med. 2020 Jun;48(6):e514-e522. doi: 10.1097/CCM.0000000000004345.

Contemporary strategies to improve clinical trial design for critical care research: insights from the First Critical Care Clinical Trialists Workshop.当代改善重症监护研究临床试验设计的策略：来自第一届重症监护临床试验家研讨会的见解。

Intensive Care Med. 2020 May;46(5):930-942. doi: 10.1007/s00134-020-05934-6. Epub 2020 Feb 18.

Improved survival in critically ill patients: are large RCTs more useful than personalized medicine? No.危重症患者生存率的提高：大型随机对照试验比个性化医疗更有用吗？并非如此。

Intensive Care Med. 2016 Nov;42(11):1778-1780. doi: 10.1007/s00134-016-4482-5. Epub 2016 Sep 12.

Multicenter randomized controlled trial of inhaled nitric oxide for pediatric acute respiratory distress syndrome.吸入一氧化氮治疗小儿急性呼吸窘迫综合征的多中心随机对照试验

J Pediatr. 2015 Feb;166(2):365-9.e1. doi: 10.1016/j.jpeds.2014.10.011. Epub 2014 Nov 12.

Low-dose inhaled nitric oxide in patients with acute lung injury: a randomized controlled trial.低剂量吸入一氧化氮治疗急性肺损伤患者：一项随机对照试验。

JAMA. 2004 Apr 7;291(13):1603-9. doi: 10.1001/jama.291.13.1603.

Multicenter randomized controlled trial of the effects of inhaled nitric oxide therapy on gas exchange in children with acute hypoxemic respiratory failure.吸入一氧化氮疗法对急性低氧性呼吸衰竭患儿气体交换影响的多中心随机对照试验

J Pediatr. 1999 Apr;134(4):406-12. doi: 10.1016/s0022-3476(99)70196-4.

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Severity of hypoxemia may explain indeterminate results in pediatric trials of inhaled nitric oxide.

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