Kenya Medical Research Institute (KEMRI), Wellcome Trust Research Programme, Kilifi, Kenya.
Medical Research Council Clinical Trials Unit (MRC CTU) at University College, London, UK.
Br J Haematol. 2021 Jun;193(5):894-901. doi: 10.1111/bjh.17431. Epub 2021 May 15.
Owing to the rapid turnaround time in the assessment of haemoglobin level by point-of-care tests (POC Hb), these have grown in popularity and scope in large parts of the world. However, whilst POC testing for malaria and HIV remains has been integrated into patient management in Africa, the use of POC haemoglobin testing remains neglected by health services. The main users of transfusions (paediatric, maternity and trauma services) present largely as emergencies. Ward-based POC Hb could result in more rapid and accurate diagnosis of anaemia, contributing to saving of lives and at the same time reduce unnecessary transfusions which deplete the limited supplies of donated blood in Africa. Severe anaemia requiring transfusion is a major cause of paediatric admission in Africa. At a dissemination meeting to discuss the results of a large phase III paediatric transfusion trial and steps to implementation of the findings participants strongly recommended that one of the most pressing actions required was to prioritise the use of POC haemoglobin testing. This would facilitate implementation of the new transfusion algorithm, developed at the meeting, which refines patient management including blood transfusions. We present the rationale for the strongly recommended prioritisation of POC Hb, using paediatric transfusion as an exemplar.
由于即时检测(point-of-care test, POC)血红蛋白检测在评估血红蛋白水平方面的快速周转时间,这些检测在世界上许多地区的应用范围和受欢迎程度都有所增加。然而,尽管即时检测疟疾和艾滋病毒的检测已经被整合到非洲的患者管理中,但即时检测血红蛋白检测在卫生服务中仍未得到重视。输血的主要使用者(儿科、产科和创伤科)主要以急诊形式出现。病房内的即时检测血红蛋白可以更快速和准确地诊断贫血,有助于拯救生命,同时减少不必要的输血,因为这会消耗非洲有限的献血供应。需要输血的严重贫血是非洲儿科住院的主要原因。在一次讨论大型 III 期儿科输血试验结果和实施这些发现的步骤的传播会议上,与会者强烈建议,最紧迫的行动之一是优先使用即时检测血红蛋白检测。这将有助于实施在会议上制定的新的输血算法,该算法细化了包括输血在内的患者管理。我们以儿科输血为例,提出强烈建议优先考虑即时检测血红蛋白检测的理由。