Urban Lauren A, Trinh Annie, Pearlman Eric, Siryaporn Albert, Downing Timothy L
Department of Microbiology and Molecular Genetics, University of California-Irvine, Irvine, CA 92697, USA; The Edwards Lifesciences Center for Advanced Cardiovascular Technology, University of California-Irvine, Irvine, CA 92697, USA.
Institute for Immunology, University of California-Irvine, Irvine, CA 92697, USA; Department of Ophthalmology, University of California-Irvine, Irvine, CA 92697, USA; Department of Physiology and Biophysics, University of California-Irvine, Irvine, CA 92697, USA.
Trends Immunol. 2021 Jun;42(6):464-468. doi: 10.1016/j.it.2021.04.005. Epub 2021 May 11.
Aging is associated with decreased antigen-specific immunity and increased chronic inflammation. While DNA-sensing pathways might be involved, the molecular factors underlying these age-related aberrancies in immune signaling are unclear. Here, we consider the potential role of aging-induced hypomethylated DNA as a putative stimulant of age-associated inflammation.
衰老与抗原特异性免疫功能下降和慢性炎症增加有关。虽然DNA传感途径可能参与其中，但免疫信号中这些与年龄相关异常的分子因素尚不清楚。在这里，我们探讨衰老诱导的DNA低甲基化作为年龄相关炎症的假定刺激物的潜在作用。
