核小体的统计分布：通过随机机制确定的非随机位置
Statistical distributions of nucleosomes: nonrandom locations by a stochastic mechanism.
作者信息
Kornberg R D, Stryer L
机构信息
Department of Cell Biology, Stanford University School of Medicine, CA 94305.
出版信息
Nucleic Acids Res. 1988 Jul 25;16(14A):6677-90. doi: 10.1093/nar/16.14.6677.
Abstract
Expressions are derived for distributions of nucleosomes in chromatin. Nucleosomes are placed on DNA at the densities found in bulk chromatin, and their locations are allowed to vary at random. No further assumptions are required to simulate the periodic patterns of digestion obtained with various nucleases. The introduction of a boundary constraint, due for example to sequence-specific protein binding, results in an array of regularly spaced nucleosomes at nonrandom locations, similar to the arrays reported for some genes and other chromosomal regions.
摘要
推导了染色质中核小体分布的表达式。核小体以在整体染色质中发现的密度放置在DNA上，并且它们的位置允许随机变化。模拟用各种核酸酶获得的消化的周期性模式不需要进一步的假设。例如，由于序列特异性蛋白质结合而引入的边界约束导致在非随机位置出现一系列规则间隔的核小体，类似于一些基因和其他染色体区域报道的阵列。
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